Zobrazeno 1 - 10
of 148
pro vyhledávání: '"M-Phase Promoting Factor"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1997 Feb . 94(4), 1194-1199.
Externí odkaz:
https://www.jstor.org/stable/41307
Autor:
Edmond Fleischer, Vincent Kam Wai Wong, Thorsten Berg, Sara Abdelfatah, Thomas Efferth, Anette Klinger, Li Jun Yang, Qi Huang, Sami Hamdoun, Henry Johannes Greten, Angela Berg
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Po
Autor:
Bement, William M., Capco, David G.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1991 Jun . 88(12), 5172-5176.
Externí odkaz:
https://www.jstor.org/stable/2356914
Autor:
Minoru Irahara, Kenji Hinokio, Yuya Yano, Toshiyuki Yasui, Akira Kuwahara, Shuji Yamano, Tomomi Iba, Mayumi Umeno
Publikováno v:
Zygote. 20:321-325
SummaryThe aim of the present study was to determine oocyte activation and change in M-phase promoting factor (MPF) activity induced by treatment with calcium ionophore and roscovitine in comparison with those induced by treatment with roscovitine al
Autor:
Bingzhi Yu, Jian-Ying Xiao, Fuquan Yang, Jun Meng, Cheng Cui, Didi Wu, Xiao-Han Sun, Huiyu Fan, Chao Liu, Junjie Hou, En-Hua Wang
Publikováno v:
Journal of Biological Chemistry. 286:10356-10366
It is well documented that protein kinase A (PKA) acts as a negative regulator of M phase promoting factor (MPF) by phosphorylating cell division cycle 25 homolog B (Cdc25B) in mammals. However, the molecular mechanism remains unclear. In this study,
Autor:
Kiyoshi Kano, Yukio Nishimura, Mari Suzuki, Kunihiko Naito, Wataru Fujii, Tadashi Yamamuro, Takuma Shimaoka, Takanori Nishimura
Publikováno v:
Journal of Mammalian Ova Research. 27:27-34
Maturation/M-phase promoting factor (MPF) activity is regulated by the Cyclin B concentration and phosphorylation states of Cdc2 kinase. In the present review, we summarize the factors regulating the synthesis and degradation of Cyclin B and the phos
Autor:
Mary Ann F. Petrunewich, James R. Trimarchi, Mary-Anne Hammer, Jay M. Baltz, Amy Katherine Lindsey Hanlan
Publikováno v:
Journal of Reproduction and Development. 55:30-38
ERK-type MAP kinase activity is required for normal first meiotic (MI) metaphase spindle dynamics and first polar body formation at the MI/MII transition, and for MII arrest until egg activation. MEK and MAPK, however, remain active until meiosis is
Publikováno v:
REPRODUCTION. 136:741-752
Fertilization affects levels of cyclin B1 and M-phase promoting factor (MPF) activity in maturing and metaphase II mouse oocytes in two distinct ways. In metaphase II oocytes, it leads to a Ca2+-dependent, continuous degradation of cyclin B1 and inac
Autor:
Zhe Zhang, Cheng Cui, Hongmei Zhao, Yang Zhang, Bingzhi Yu, Xiao-Yan Xu, Zhi-Hong Zong, Xin Deng, Chen Feng
Publikováno v:
Biology of Reproduction. 79:991-998
Protein kinase A (PRKACA) has been documented as a pivotal regulator in meiosis and mitosis arrest. Although our previous work has established that PRKACA regulates cell cycle progression of mouse fertilized eggs by inhibiting M-phase promoting facto
Autor:
Jie Zhang, Ying Liu, Wen-hui Su, Bingzhi Yu, Zhe Zhang, Dahai Yu, Qing-Yuan Sun, Aiming Yu, Chen Feng, Zhi-Hong Zong
Publikováno v:
Biology of Reproduction. 77:560-568
The activation of AKT (also called protein kinase B) is thought to be a critical step in the phosphoinositide 3-kinase pathway that regulates cell growth and differentiation. In this report, we investigated the role of AKT in the regulation of mouse