Zobrazeno 1 - 10 of 69 pro vyhledávání: '"M-L. Schmidt"'
5
A porcine model system of BRCA1 driven breast cancer
Autor: M. L. Schmidt, Eric M. Walters, Katharine R. Hobbing, Howard Donninger, Geoffrey J. Clark, Laurie A. Rund, Lawrence B. Schook
Publikováno v: Frontiers in Genetics, Vol 6 (2015)
Frontiers in Genetics
BRCA1 is a breast and ovarian tumor suppressor. Hereditary mutations in BRCA1 result in a predisposition to breast cancer, and BRCA1 expression is down-regulated in ~30% of sporadic cases. The function of BRCA1 remains poorly understood, but it appea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140ec72242363e964d5fc83029484fef
https://doi.org/10.3389/fgene.2015.00269
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7
Abstract 1483: Alteration of miR-186 expression modifies inflammatory markers in normal epithelial and prostate cancer cell models
Autor: LaCreis R. Kidd, Dominique Z. Jones-Reed, Kevin S. Kimbro, Suman Suman, Carolyn M. Klinge, M. L. Schmidt, Geoffrey J. Clark, Shirish Barve
Publikováno v: Cancer Research. 77:1483-1483
Dysregulation of miRNAs and chronic inflammation are strongly implicated in the development of various malignancies, including prostate cancer (PCa). Previously, our lab identified several inflammatory and immune response sequence variants in CCL5 an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9897baa412149189ea0ebbb7ae0c19ec
https://doi.org/10.1158/1538-7445.am2017-1483
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8
NORE1A Regulates MDM2 Via β-TrCP
Autor: M. L. Schmidt, Diego F. Calvisi, Geoffrey J. Clark
Publikováno v: Cancers
Cancers; Volume 8; Issue 4; Pages: 39
Cancers, Vol 8, Iss 4, p 39 (2016)
Mouse Double Minute 2 Homolog (MDM2) is a key negative regulator of the master tumor suppressor p53. MDM2 regulates p53 on multiple levels, including acting as an ubiquitin ligase for the protein, thereby promoting its degradation by the proteasome.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0109d4f6b77c71e1a67839c36fd87b1
https://doi.org/10.3390/cancers8040039
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9
Recombinant activated factor VII (rFVIIa) therapy for intracranial hemorrhage in hemophilia a patients with inhibitors
Autor: S. Gamerman, Horace E Smith, M. L. Schmidt, Donna DiMichele, Scott Jp
Publikováno v: American Journal of Hematology. 47:36-40
We report the use of recombinant VIIa (rFVIIa) in the treatment of five ICHs in two factor VIII-deficient patients with inhibitors. In four of five ICHs, rFVIIa was the only factor replacement used at doses of 60-135 micrograms/kg every 2-4 hr for 12
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1aaa316b6c47097ecdfb070467b639
https://doi.org/10.1002/ajh.2830470108
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10
Abstract 3085: MicroRNA-186 inhibition alters cell proliferation and colony formation in prostate cancer
Autor: LaCreis R. Kidd, Dominique Jones, Katharine R. Hobbing, M. L. Schmidt, Geoffrey J. Clark
Publikováno v: Cancer Research. 75:3085-3085
MicroRNAs (miRs), key regulators of cancer-related genes, are dysregulated in many solid tumors, including prostate cancer. However, the role of miR-186 in prostate cancer (PCA) requires further elucidation. Previously, we observed mature miR-186-5p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10bcb934261d1ad1ae5addc67b4e897a
https://doi.org/10.1158/1538-7445.am2015-3085
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