Human T cell repertoire generation in the absence of MHC class II expression results in a circulating CD4+CD8- population with altered physicochemical properties of complementarity-determining region 3

Autor: J Henwood, M C van Eggermond, A H van Boxel-Dezaire, R Schipper, M den Hoedt, A Peijnenburg, O Sanal, F Ersoy, G T Rijkers, B J Zegers, J M Vossen, M J van Tol, P J van den Elsen

Publikováno v: The Journal of Immunology. 156:895-906

In this study, we have investigated the impact of deficient MHC class II expression on the use of TCRBV6 and TCRBJ gene elements, and on the pattern of amino acid incorporation exhibited in the N1-D-N2 segments of the third complementarity-determinin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2293300e5e255c3a3abc185fb83903d4
https://doi.org/10.4049/jimmunol.156.3.895

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The sphingosine 1-phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus.

Autor: Magalhães DM; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Lisboa, Portugal.; School of Applied Sciences, University of Brighton, Brighton, UK., Stewart NA; School of Applied Sciences, University of Brighton, Brighton, UK., Mampay M; School of Applied Sciences, University of Brighton, Brighton, UK., Rolle SO; Green Templeton College, University of Oxford, Oxford, UK., Hall CM; School of Applied Sciences, University of Brighton, Brighton, UK.; Department of Mechanical Engineering, University College London, London, UK., Moeendarbary E; Department of Mechanical Engineering, University College London, London, UK.; 199 Biotechnologies Ltd, London, UK., Flint MS; School of Applied Sciences, University of Brighton, Brighton, UK., Sebastião AM; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Lisboa, Portugal., Valente CA; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Lisboa, Portugal., Dymond MK; School of Applied Sciences, University of Brighton, Brighton, UK., Sheridan GK; School of Life Sciences, University of Nottingham, Nottingham, UK.

Publikováno v: Journal of neurochemistry [J Neurochem] 2024 Jun; Vol. 168 (6), pp. 1113-1142. Date of Electronic Publication: 2024 Feb 09.