Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936

Autor: O. K. L. Hamilton, S. R. Cox, J. A. Okely, F. Conte, L. Ballerini, M. E. Bastin, J. Corley, A. M. Taylor, D. Page, A. J. Gow, S. Muñoz Maniega, P. Redmond, M. del C. Valdés-Hernández, J. M. Wardlaw, I. J. Deary

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD’s association with slowed processing might be due to its association with overall decl

Externí odkaz: https://doaj.org/article/e0141e9818e44b3dbc7b47d1ee3ca493

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936

Autor: David C. Page, Alan J. Gow, Ian J. Deary, Olivia K.L. Hamilton, M. del C. Valdés-Hernández, Paul Redmond, Simon R. Cox, Joanna M. Wardlaw, Adele M. Taylor, Lucia Ballerini, Janie Corley, Mark E. Bastin, S. Muñoz Maniega, F. Conte, Judith A. Okely

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Hamilton, O, Cox, S R, Okely, J, Conte, F, Ballerini, L, Bastin, M E, Corley, J, Taylor, A, Page, D, Gow, A, Muñoz Maniega, S, Redmond, P, Valdés Hernández, M C, Wardlaw, J M & Deary, I J 2021, ' Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936 ', Translational Psychiatry . https://doi.org/10.1038/s41398-021-01495-4
Transl Psychiatry.
Translational Psychiatry

Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD’s association with slowed processing might be due to its association with overall declining gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793cca7f01c6f1f6f8d066eb36f1c1da
https://doaj.org/article/e0141e9818e44b3dbc7b47d1ee3ca493

Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936

Autor: Catherine Murray, S. Muñoz Maniega, Natalie A. Royle, Jeremy Hall, Joanna M. Wardlaw, Michelle Luciano, M. del C. Valdés Hernández, Stephen M. Lawrie, Mark E. Bastin, John M. Starr, Ian J. Deary, Andrew M. McIntosh

Publikováno v: McIntosh, A M, Bastin, M E, Luciano, M, Munoz-Maniega, S, Valdes Hernandez, M, Royle, N A, Hall, J, Murray, C, Lawrie, S M, Starr, J M, Wardlaw, J M & Deary, I J 2013, ' Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936 ', Psychological Medicine, vol. 43, no. 6, pp. 1197-1206 . https://doi.org/10.1017/S003329171200150X

BackgroundClinical depression is associated with reductions in white-matter integrity in several long tracts of the brain. The extent to which these findings are localized or related to depressive symptoms or personality traits linked to disease risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afb671a0c32047546d228a39ab615ec
https://doi.org/10.1017/s003329171200150x

Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Autor: D M, Lyall, S E, Harris, M E, Bastin, S, Muñoz Maniega, C, Murray, M W, Lutz, A M, Saunders, A D, Roses, M del C, Valdés Hernández, N A, Royle, J M, Starr, D J, Porteous, J M, Wardlaw, I J, Deary

Publikováno v: Translational Psychiatry

Genetic polymorphisms in the APOE ɛ and TOMM40 '523' poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer's disease. This study investigated the independent effects of these polymorphisms on human cognitive age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14d722acc83ccfe6b42a33e4916fee30
https://pubmed.ncbi.nlm.nih.gov/25247594

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