Zobrazeno 1 - 10
of 35
pro vyhledávání: '"M Zaigler"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 43:327-334
Objective Triamterene (TA), a potassium-sparing diuretic, is extensively metabolized by hydroxylation in 4'-position and subsequent conjugation by cytosolic sulfotransferases. To identify the cytochrome P450 enzyme(s) catalyzing hydroxylation of tria
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 42:543-549
Background and objectives: The antimuscarinic drug trospium chloride is hydrophilic and therefore does not enter the CNS when used for the treatment of overactive bladder disturbances. However, the same property is the main reason for low and variabl
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 38:1-9
Pronounced interindividual differences in drug disposition are mainly caused by differences in the activity of liver drug-metabolizing enzymes. These depend on known and unknown covariates, including genetic as well as environmental factors. Phenotyp
Autor:
Matthias Schwab, S. Wilde, M Zaigler, Volker Diehl, S. Rietbrock, Ulrich Jaehde, M. Sieber, S. Reif, Georg Hempel, Alexander Jetter, H. Tesch, Uwe Fuhr, Dagmar Busse, H. Menzel
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 40:586-588
Publikováno v:
International journal of clinical pharmacology and therapeutics. 38(5)
Background and objectives The activity of the human cytochrome P450 CYP1A2 is decreased by female sex hormones during pregnancy or treatment with oral contraceptives. However, the influence of menstrual cycle on CYP 1A2 activity is not clear. Methods
Publikováno v:
International journal of clinical pharmacology and therapeutics. 37(11)
Omeprazole is an inducer of human cytochrome P450 1A (CYP1A) enzymes, but shows inhibitory effects on CYP2C19 and CYP3A4. In this study, a potential inhibitory effect of omeprazole on caffeine metabolism, a validated CYP1A2 marker, was examined.A ran
Publikováno v:
Pharmacogenetics. 9(2)
A pronounced variability limits the usefulness of CYP1A2 phenotyping for drug therapy, for evaluating liver function, and for assessing the role of this enzyme in carcinogenesis. To identify and quantify sources of this variation, we estimated CYP1A2
Autor:
M, Zaigler
Publikováno v:
Der Internist. 39(9)
Autor:
U, Fuhr, A, Maier-Brüggemann, H, Blume, W, Mück, S, Unger, J, Kuhlmann, C, Huschka, M, Zaigler, S, Rietbrock, A H, Staib
Publikováno v:
International journal of clinical pharmacology and therapeutics. 36(3)
The bioavailability of dihydropyridine calcium channel blockers following oral administration was shown to be increased by concomitant intake of grapefruit juice for all drugs of this class tested up to now. Here we report a randomized crossover inte
Autor:
U. Fuhr, M. Zaigler
Publikováno v:
Ersatz-und Ergänzungsmethoden zu Tierversuchen ISBN: 9783211830451
Ersatz-und Ergänzungsmethoden zu Tierversuchen
Ersatz-und Ergänzungsmethoden zu Tierversuchen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf98e37c2f96b3d8d344f4857a759a28
https://doi.org/10.1007/978-3-7091-7500-2_8
https://doi.org/10.1007/978-3-7091-7500-2_8