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Akademický článek

Modulators of endogenous cannabinoid system аs neuroprotectors

Autor: E. E. Genrikhs, M. Yu. Bobrov, E. L. Andrianova, N. M. Gretskaya, A. A. Lyzhin, A. V. Blazhenova, L. E. Frumkina, V. V. Bezuglov, L. G. Khaspekov

Publikováno v: Анналы клинической и экспериментальной неврологии, Vol 4, Iss 4, Pp 37-42 (2017)

The neuroprotective action of endocannabinoid N-arachidonoyldopamine(AA-DA) in the model of apoptosis induced incultured rat cerebellar granule neurons by K+ deprivation wasinvestigated. The efficacy of simultaneous application of AA-DAwith fatty aci

Externí odkaz: https://doaj.org/article/55a6978d95e2428a96ad56bbee5a6f13

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Akademický článek

Plastic reorganization of hippocampal synapses resulted from pharmacological blockade of type 1 cannabinoid receptors

Autor: L. E. Frumkina, M. Yu. Bobrov, A. A. Lyzhin, E. L. Andrianova, S. K. Koroleva, N. A. Bobrova, L. G. Khaspekov

Publikováno v: Анналы клинической и экспериментальной неврологии, Vol 1, Iss 2, Pp 17-21 (2007)

Endogenous cannabinoid system plays an important physiologicalrole in brain functioning, being related to regulation of neuromediatorprocesses and mechanisms of neuroplasticity.Cannabinoid receptors of type 1 (CB1) represent one of the keyelements of

Externí odkaz: https://doaj.org/article/0d8f799af4f04fd88d148d379f06b262

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Blood Lipids Profiling of Preterm Neonates in the First Day of Life for Identification of Early Biomarkers of Sepsis and Pneumonia

Autor: M. Yu. Bobrov, O. V. Ionov, A. R. Kirtbaya, V. V. Chagovets, I. V. Nikitina, Ch. M. El'darov

Publikováno v: Russian Journal of Bioorganic Chemistry. 45:165-172

The early period of postnatal development of premature infants is often complicated by bacterial infections, in particular respiratory infections, which in adverse course can be transformed into generalized forms (sepsis), leading to life-threatening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e7030700ae9caf13e4540da1df73260
https://doi.org/10.1134/s1068162019020031

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Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine and N-docosahexaenoyl dopamine examined in neuronal precursors derived from human pluripotent stem cells

Autor: E. S. Manuilova, Leonid G. Khaspekov, M. Yu. Bobrov, Vladimir V. Bezuglov, Sergey N. Illarioshkin, E. L. Arsenyeva, Igor A. Grivennikov, E. V. Novosadova

Publikováno v: Biochemistry (Moscow). 82:1367-1372

Neuroprotective properties of endocannabinoids N-arachidonoyl dopamine (NADA) and N-docosahexaenoyl dopamine (DHDA) were examined in neuronal precursor cells differentiated from human induced pluripotent stem cells and subjected to oxidative stress.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c954db66895bf72521c0bd7633d2192b
https://doi.org/10.1134/s0006297917110141

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Metabolomic profiling in culture media of day-5 human embryos

Autor: N. P. Makarova, E A Kalinina, D. Yu. Trofimov, I M Zorina, V. Yu. Smolnikova, Ch. M. El'darov, S A Yarigina, M Yu Bobrov

Publikováno v: Biomeditsinskaya Khimiya. 63:385-391

The aim of this study was to determine the changes of metabolomic profiles in embryonic culture media (ECM) for the evaluation of quality and implantation potential of human embryos. ECM (n=163) were collected on day 5 before transfer or cryopreserva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc8daf8bb7d7dc7b2518bd8ccb4cba6
https://doi.org/10.18097/pbmc20176305385

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Early-life N-arachidonoyl-dopamine exposure increases antioxidant capacity of the brain tissues and reduces functional deficits after neonatal hypoxia in rats

Autor: I. Sukhanova, M. Yu. Bobrov, D.D. Khukhareva, Vladimir V. Bezuglov, E. A. Sebentsova, M.Yu. Vysokikh, N. Levitskaya

Publikováno v: International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceReferences. 78

Perinatal hypoxia-ischemia is one of the most common causes of perinatal brain injury and subsequent neurological disorders in children. The aim of this work was to evaluate the potential antioxidant and neuroprotective effects of N-arachidonoyl-dopa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876a905fc3e23c9fc285e27f336993d6
https://pubmed.ncbi.nlm.nih.gov/31369794

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The effect of N-arachidonoyldopamine on the dynamics of the intracellular calcium concentration in hippocampal neurons in the model of postischemic epileptogenesis in vitro

Autor: I. N. Sharonova, L. G. Khaspekov, V. V. Simonova, M. Yu. Bobrov, S. N. Kolbaev

Publikováno v: Neurochemical Journal. 10:312-317

We studied the dynamics of the intracellular concentration of calcium ions ([Ca2+]i) and the influence of the endogenous cannabinoid N-arachidonoyldopamine (N-ADA) on disturbances of calcium homeostasis in cultured hippocampal neurons in the model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38c8892c43d3b9e88221d48a60ffaebd
https://doi.org/10.1134/s1819712416040061

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Selective Action of N-Arachidonoyl Dopamine on Viability and Proliferation of Stromal Cells from Eutopic and Ectopic Endometrium

Autor: A. M. Ashba, I. A. Fedorova-Gogolina, Natalia Gretskaya, M. N. Yushina, M. Yu. Bobrov, Vladimir V. Bezuglov, S. V. Pavlovich, A. G. Melkumyan

Publikováno v: Bulletin of experimental biology and medicine. 167(1)

We performed a comparative study of the cytotoxic effect of endocannabinoid N-arachidonoyl dopamine (AA-DA) on cultured stromal cells of ectopic and eutopic endometrium. It was found that AA-DA in the concentration range of 1-20 μM produces more sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd199440a06e4a194691459dbbcb572f
https://pubmed.ncbi.nlm.nih.gov/31177459

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