Zobrazeno 1 - 10
of 413
pro vyhledávání: '"M Wolska"'
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 999 (2024)
Novel therapies for the treatment of familial dilated cardiomyopathy (DCM) are lacking. Shaping research directions to clinical needs is critical. Triggers for the progression of the disorder commonly occur due to specific gene variants that affect t
Externí odkaz:
https://doaj.org/article/b64885e49c784f88b7394ce904f21837
Autor:
Paulina Langa, Richard J. Marszalek, Chad M. Warren, Shamim K. Chowdhury, Monika Halas, Ashley Batra, Koreena Rafael-Clyke, Angelie Bacon, Paul H. Goldspink, R. John Solaro, Beata M. Wolska
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Hypertrophic cardiomyopathy (HCM) is a cardiovascular genetic disease caused largely by sarcomere protein mutations. Gaps in our understanding exist as to how maladaptive sarcomeric biophysical signals are transduced to intra- and extra
Externí odkaz:
https://doaj.org/article/e99641809e6e470d9ce61d862b63471e
Autor:
Tuchakorn Lertwanakarn, Montamas Suntravat, Elda E. Sánchez, Beata M. Wolska, R. John Solaro, Pieter P. de Tombe, Kittipong Tachampa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Beta-cardiotoxin (β-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel β-adrenergic blocker. However, the involvement of β-adrenergic signaling by this compound has never been elucidated. The objectives
Externí odkaz:
https://doaj.org/article/12b4e1c459b840caa3612cef138d7e12
Autor:
Christopher Solís, Walter C. Thompson, James R. Peña, Christopher McDermott-Roe, Paulina Langa, Chad M. Warren, Magdalena Chrzanowska, Beata M. Wolska, R. John Solaro, Pieter Detombe, Paul H. Goldspink
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In the heart, alternative splicing of the igf-I gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor, MGF). The sequence divergence between their E-domain regions suggests differential isoform function. To define the biological act
Externí odkaz:
https://doaj.org/article/4276e5406b9d47d2af2e397c632f998a
Autor:
Andrielle E. Capote, Ashley Batra, Chad M. Warren, Shamim A. K. Chowdhury, Beata M. Wolska, R. John Solaro, Paola C. Rosas
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Experiments reported here tested the hypothesis that β-arrestin-2 is an important element in the preservation of cardiac function during aging. We tested this hypothesis by aging β-arrestin-2 knock-out (KO) mice, and wild-type equivalent (WT) to 12
Externí odkaz:
https://doaj.org/article/dd5211b59a5f480daa17eb7fdc020ff5
Autor:
Nataša Vaupotič, Damian Pociecha, Paulina Rybak, Joanna Matraszek, Mojca Čepič, Joanna M. Wolska, Ewa Gorecka
Publikováno v:
Liquid Crystals. :1-12
We studied dielectric properties of a polar nematic phase (NF) sandwiched between two gold or ITO electrodes, serving as a cell surfaces. In bulk, NF is expected to exhibit a Goldstone mode (phason), because polarization can uniformly rotate with no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cfb7a64ab22ce8be376c6c97725bdf
https://doi.org/10.1080/02678292.2023.2180099
https://doi.org/10.1080/02678292.2023.2180099
Autor:
Tuchakorn Lertwanakarn, Montamas Suntravat, Elda E. Sanchez, Worakan Boonhoh, R. John Solaro, Beata M. Wolska, Jody L. Martin, Pieter P. de Tombe, Kittipong Tachampa
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Abstract Background: Beta-cardiotoxin (β-CTX), the three-finger toxin isolated from king cobra (Ophiophagus hannah) venom, possesses β-blocker activity as indicated by its negative chronotropy and its binding property to both β-1 and β-2 adrenerg
Externí odkaz:
https://doaj.org/article/1ca590cc3ac341a5996d7e7a27a489be
Autor:
Shamim A. K. Chowdhury, Chad M. Warren, Jillian N. Simon, David M. Ryba, Ashley Batra, Peter Varga, Evangelia G. Kranias, Jil C. Tardiff, R. John Solaro, Beata M. Wolska
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a “disease of the sarcomere.” Despite the discovery of sarcomere protein mutations linked to
Externí odkaz:
https://doaj.org/article/4f5f102bf0564eda9c95446b3789c405
Autor:
Paulina Langa, Sanam Shafaattalab, Paul H. Goldspink, Beata M. Wolska, Aurelia A. Fernandes, Glen F. Tibbits, R. John Solaro
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
In this perspective, we discussed emerging data indicating a role for Notch signalling in inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) linked to variants of genes encoding m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5baddbd4579b67f0e0fcb96fd298a19d
https://doi.org/10.1098/rstb.2022.0176
https://doi.org/10.1098/rstb.2022.0176
Autor:
Srikanth Perike, Francisco J. Gonzalez-Gonzalez, Issam Abu-Taha, Frederick W. Damen, Ken S. Lizama, Anahita Aboonabi, Andrielle E. Capote, Yuriana Aguilar-Sanchez, Benjamin Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Jody Martin, Joseph G. Akar, Chad M. Warren, R. John Solaro, Sang-Ging Ong, Dawood Darbar, Craig J. Goergen, Beata M. Wolska, Dobromir Dobrev, Xander H.T. Wehrens, Mark D. McCauley
Publikováno v:
bioRxiv
BackgroundAtrial fibrillation (AF), the most common sustained cardiac arrhythmia, increases thromboembolic stroke risk five-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce117be4822bc8b8878209663dbe4ad8
https://europepmc.org/articles/PMC10153354/
https://europepmc.org/articles/PMC10153354/
