Zobrazeno 1 - 10
of 19
pro vyhledávání: '"M W Verghese"'
Autor:
J J Lorenz, P J Furdon, J D Taylor, M W Verghese, G Chandra, T A Kost, S A Haneline, L A Roner, J G Gray
Publikováno v:
The Journal of Immunology. 155:836-844
IL-1 beta is a cytokine generally considered to be a major component involved in the pathogenesis of rheumatoid arthritis and other inflammatory diseases. Of the agents found in high concentrations in inflamed rheumatoid arthritis joints, TNF-alpha i
Autor:
L, Sekut, B, Han, P, Baer, M W, Verghese, R, Silverstein, L, Clifton, S, Dennis, M J, Numerick, K M, Connolly
Publikováno v:
Laboratory animal science. 45(6)
Using tumor necrosis factor (TNF) inhibition in dog blood as a measure of efficacy, and canine emesis as a measure of toxicity, we were able to assign a therapeutic index to rolipram, a prototypic anti-inflammatory compound. Because both assays were
Autor:
J J, Lorenz, P J, Furdon, J D, Taylor, M W, Verghese, G, Chandra, T A, Kost, S A, Haneline, L A, Roner, J G, Gray
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(2)
IL-1 beta is a cytokine generally considered to be a major component involved in the pathogenesis of rheumatoid arthritis and other inflammatory diseases. Of the agents found in high concentrations in inflamed rheumatoid arthritis joints, TNF-alpha i
Publikováno v:
Molecular pharmacology. 47(6)
Many functions of the immune and inflammatory responses are inhibited by agents that increase intracellular levels of cAMP. Recent investigations have revealed that cAMP levels in inflammatory cells are regulated by cyclic nucleotide phosphodiesteras
Autor:
M W, Verghese, R T, McConnell, A B, Strickland, R C, Gooding, S A, Stimpson, D P, Yarnall, J D, Taylor, P J, Furdon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(3)
Elevation of cAMP downregulates certain functions of inflammatory cells, including the release of TNF alpha and IL-1 beta by macrophages. Intracellular cAMP levels can be modulated pharmacologically by adding cell-permeable cAMP analogs, by stimulati
Publikováno v:
The Journal of Immunology. 138:4374-4380
It is well established that formyl peptide chemoattractants can activate a phospholipase C in leukocytes via a pertussis toxin (PT)-sensitive guanine nucleotide regulatory (G) protein. Whether this pathway is similarly used by chemoattractant recepto
Autor:
M W Verghese, R Snyderman
Publikováno v:
The Journal of Immunology. 128:608-613
Autor:
M W Verghese, R Snyderman
Publikováno v:
The Journal of Immunology. 127:288-293
Most mouse strains are highly susceptible to endotoxin (LPS) lethality and are responsive to LPS stimulation in vitro (e.g., B cell mitogenesis, macrophage activation). They are, however, capable of mounting only a small inflammatory response to LPS
Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides
Autor:
M W Verghese, R Snyderman
Publikováno v:
The Journal of Immunology. 130:869-873
Many macrophage functions such as chemotaxis, phagocytosis, enzyme secretion, and cytotoxicity are influenced by intracellular cyclic nucleotide levels, but the regulatory mechanisms involved are poorly defined. We have developed methods that allowed
Autor:
M W, Verghese, R, Snyderman
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 127(1)
Most mouse strains are highly susceptible to endotoxin (LPS) lethality and are responsive to LPS stimulation in vitro (e.g., B cell mitogenesis, macrophage activation). They are, however, capable of mounting only a small inflammatory response to LPS