Výsledky vyhledávání

HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression

Autor: Irena Stefanova, Noreen Jack, William A. Blattner, Robert Yarchoan, Kent J. Weinhold, Courtenay Bartholomew, C Peters, Joseph B. Bolen, Farley R. Cleghorn, David Venzon, Ivan D. Horak, David A. Schwartz, M W Saville

Publikováno v: Journal of Clinical Investigation. 98:1290-1297

In attempt to elucidate the mechanism of the HIV infection induced T cell unresponsiveness, we studied signal-transducing molecules proximal to the T cell receptor (TCR) in T lymphocytes of HIV-infected individuals. Total amounts of protein tyrosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b19c41c6c49117832419b072755e4c6
https://doi.org/10.1172/jci118915

Zobrazit plný text záznamu

Healthcare utilization and costs associated with skeletal-related events in prostate cancer patients with bone metastases

Autor: T E Delea, M W Saville, Karen Chung, M Hagiwara

Publikováno v: Prostate cancer and prostatic diseases. 16(1)

Patients with bone metastases secondary to prostate cancer are predisposed to skeletal-related events (SREs), including spinal cord compression, pathological fracture, surgery to bone and radiotherapy to bone. The objective of this study was to docum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051bba30526551725249fbe29f8f9c15
https://pubmed.ncbi.nlm.nih.gov/23146970

Zobrazit plný text záznamu

Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways

Autor: D J Altman, Vera Klaus-Kovtun, M W Saville, Robert Yarchoan, Andrew Blauvelt, Stephen I. Katz, Hideo Asada

Publikováno v: The Journal of clinical investigation. 100(8)

There is substantial evidence that dendritic cells (DC) residing within epithelial surfaces (e.g., Langerhans cells) are the initial cells infected with HIV after mucosal exposure to virus. To study DC-HIV interactions in detail, we propagated Langer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85935b4049832576efcee092acfd2116
https://pubmed.ncbi.nlm.nih.gov/9329969

Zobrazit plný text záznamu

AIDS-related malignancies

Autor: M W, Saville

Publikováno v: Cancer chemotherapy and biological response modifiers. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5ce2b58118c83d8e8a31d1262c5f709
https://pubmed.ncbi.nlm.nih.gov/9551223

Zobrazit plný text záznamu

The pharmacokinetics of TNP-470, a new angiogenesis inhibitor

Autor: W D, Figg, J M, Pluda, R M, Lush, M W, Saville, K, Wyvill, E, Reed, R, Yarchoan

Publikováno v: Pharmacotherapy. 17(1)

To characterize the pharmacokinetic profile of TNP-470, a synthetic analog of fumagillin that is a potent inhibitor of angiogenesis and inhibits neovascularization in several solid tumor models.A dose-escalation phase I clinical trial.The National In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c143c71550343a7b17bb24ffdbb25267
https://pubmed.ncbi.nlm.nih.gov/9017768

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání