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Glial hyaluronate-binding protein: a product of metalloproteinase digestion of versican?

Autor: M W Lark, Richard A. Asher, Amico Bignami, William S. Lane, G. Perides, R A Robinson

Publikováno v: Biochemical Journal. 312:377-384

Glial hyaluronate-binding protein (GHAP) is a 60 kDa glycoprotein with an amino acid sequence identical to that of the hyaluronate-binding region of versican, a large fibroblast aggregating proteoglycan found in the brain. Both GHAP and versican were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4acc40b6d5b0ba2fe963861a5d5eb93
https://doi.org/10.1042/bj3120377

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Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage

Autor: L. E. Chun, Jiann-Jiu Wu, M. W. Lark, David R. Eyre

Publikováno v: Journal of Biological Chemistry. 266:5625-5628

Human recombinant stromelysin-1 was shown to cleave four types of collagen (types II, IX, X, and XI) prepared from bovine and rat cartilages at specific sites. Stromelysin-1 cleaved salt-soluble native molecules of type IX collagen into two main trip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22137a9259928f269b8b683fe15c7ee3
https://doi.org/10.1016/s0021-9258(19)67640-4

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Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis

Autor: A M, Badger, S, Blake, R, Kapadia, S, Sarkar, J, Levin, B A, Swift, S J, Hoffman, G B, Stroup, W H, Miller, M, Gowen, M W, Lark

Publikováno v: Arthritis and rheumatism. 44(1)

To evaluate the effects of SB 273005, a potent, orally active nonpeptide antagonist of the integrin avbeta3 vitronectin receptor, on joint integrity in rats with adjuvant-induced arthritis (AIA).Male Lewis rats with AIA were orally dosed either proph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::688be6a668ea737e20ae76598df60846
https://pubmed.ncbi.nlm.nih.gov/11212150

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CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues

Autor: B J, Votta, J R, White, R A, Dodds, I E, James, J R, Connor, E, Lee-Rykaczewski, C F, Eichman, S, Kumar, M W, Lark, M, Gowen

Publikováno v: Journal of cellular physiology. 183(2)

We have previously demonstrated that a tartrate-resistant acid phosphatase (TRAP)-positive subpopulation of mononuclear cells isolated from collagenase digests of human osteoclastoma tissue exhibits an osteoclast phenotype and can be induced to resor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::910adb13fe036fae8fcb3f703536b766
https://pubmed.ncbi.nlm.nih.gov/10737895

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Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis

Autor: M W, Lark, G B, Stroup, S M, Hwang, I E, James, D J, Rieman, F H, Drake, J N, Bradbeer, A, Mathur, K F, Erhard, K A, Newlander, S T, Ross, K L, Salyers, B R, Smith, W H, Miller, W F, Huffman, M, Gowen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(2)

The Arg-Gly-Asp (RGD)-binding integrin alpha(V)beta(3) is highly expressed on osteoclasts and has been proposed to mediate cell-matrix adhesion required for osteoclast-mediated bone resorption. Antagonism of this receptor should prevent stable osteoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c265c9c299af6bb5e141179d3d2de53
https://pubmed.ncbi.nlm.nih.gov/10525079

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Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis

Autor: R D, Kapadia, G B, Stroup, A M, Badger, B, Koller, J M, Levin, R W, Coatney, R A, Dodds, X, Liang, M W, Lark, M, Gowen

Publikováno v: Technology and health care : official journal of the European Society for Engineering and Medicine. 6(5-6)

There is a tremendous unmet therapeutic need for the treatment of osteoporosis and osteoarthritis. The ovariectomized rat and the guinea pig are widely used animal models for the evaluation of new therapeutics for osteoporosis and osteoarthritis, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e460f05fc406af095b7eeb81564db13
https://pubmed.ncbi.nlm.nih.gov/10100939

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