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Akademický článek

Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013–16 West Africa epidemic

Autor: T. R. W. Tipton, Y. Hall, J. A. Bore, A. White, L. S. Sibley, C. Sarfas, Y. Yuki, M. Martin, S. Longet, J. Mellors, K. Ewer, S. Günther, M. Carrington, M. K. Kondé, M. W. Carroll

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

T cell responses are known to be essential in the immune response to Ebola virus infection, and the viral glycoprotein is a major antigenic target. Here the authors provide fine detail mapping of T cell antigens and their characterisation in Ebola vi

Externí odkaz: https://doaj.org/article/e6b0735d435f48e18929d44dd2c3bb84

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A189 EMERGENCY DEPARTMENT UTILIZATION AND RISK OF INTESTINAL RESECTION IS LOWER AMONG CHILDREN DIAGNOSED WITH INFLAMMATORY BOWEL DISEASE BEFORE 10 YEARS OF AGE: A MULTIPROVINCE POPULATION-BASED COHORT STUDY

Autor: E Kuenzig, H Singh, A Bitton, G G Kaplan, M W Carroll, A R Otley, T A Stukel, S Spruin, A M Griffiths, D R Mack, K Jacobson, G C Nguyen, L E Targownik, W El-Matary, E I Benchimol

Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:34-35

Background In Canada, the incidence of inflammatory bowel disease (IBD) is increasing faster among those Purpose To compare healthcare utilization and risk of surgery among children diagnosed with IBD across age groups defined by the Paris Classifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acef319efd580572530e7a20c8016e74
https://doi.org/10.1093/jcag/gwac036.189

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A183 VARIATION IN HEALTH SERVICES UTILIZATION AND RISK OF SURGERY ACROSS CHILDREN WITH INFLAMMATORY BOWEL DISEASE: A MULTIPROVINCE COHORT STUDY

Autor: E Kuenzig, H Singh, A Bitton, G G Kaplan, M W Carroll, A R Otley, T A Stukel, S Spruin, A M Griffiths, D R Mack, K Jacobson, G C Nguyen, L E Targownik, W El-Matary, S Nasiri, E I Benchimol

Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:27-28

Background Marked variation in access to care and health services utilization is a marker of variation in quality of care. With the rising incidence of pediatric inflammatory bowel disease (IBD), we must understand variation in access to and outcomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdf72815bbe0924fdbf81259ca0ba749
https://doi.org/10.1093/jcag/gwac036.183

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A47 MICROBIAL FUNCTIONS AS BIOMARKERS OF PRO-INFLAMMATORY RESPONSE TO SELECT DIETARY FIBERS IN IBD

Autor: H Armstrong, M Bording-Jorgensen, R Valcheva, Z Zhang, J Jovel, A Petrova, M W Carroll, H Q Huynh, L A Dieleman, E Wine

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:54-55

Background Dietary fibers are not digested in the bowel; they are fermented by microbes, typically promoting gut health. However, IBD patients experience sensitivity to consumption of fibers. Our previous findings offered the first mechanistic eviden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30379d0a71dac45f0127e661efd47abe
https://doi.org/10.1093/jcag/gwab049.046

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P186 Can transabdominal bowel ultrasound accurately detect both small and large bowel Crohn Disease in pediatric patients when compared to MRE?

Autor: A Hudson, H Q Huynh, H Ma, A Kuc, J Kim, P Almeida, M W Carroll, E Wine, A Thompson, D M Isaac

Publikováno v: Journal of Crohn's and Colitis. 16:i250-i251

Background Magnetic resonance enterography (MRE) has been the modality of choice to assess small bowel inflammation in patients with Crohn disease (CD). It can also assess large bowel when not feasible to assess endoscopically. Transabdominal bowel u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aa2097ac695424415e6743ae2f3d3ba
https://doi.org/10.1093/ecco-jcc/jjab232.314

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A33 MEALTIME SUPPORT: A PILOT COHORT STUDY OF AN EFFECTIVE, COST-SAVING OUTPATIENT HUNGER-BASED FEEDING PROGRAM FOR TUBE DEPENDENCY

Autor: M W Carroll, J Turner, A Vishram, G Huynh, D Blatz, C Graham-Parker

Publikováno v: Journal of the Canadian Association of Gastroenterology. 4:291-292

Background Tube dependency is an under recognized complication of long-term enteral feeding in young children. Many children struggle to progress to full oral feeds even with sufficient oral motor skills and swallowing ability. Tube dependency greatl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9b84b8ca7592676fe1f40014540dc9c
https://doi.org/10.1093/jcag/gwab002.032

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A30 ETHNIC VARIATION OF PEDIATRIC INFLAMMATORY BOWEL DISEASE IN CANADA

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with highest prevalence in the Western world. Recent temporal trends in adult and pediatric populations demonstrate increasing incidence in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba52e7e3e9a82defb33a3164ba90d78
https://europepmc.org/articles/PMC6508137/

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A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease

Autor: M W Carroll, R Hewson, A Miloszewska, Geoff Pearson, S J D Findlay-Wilson, Emma Rayner, K R Buttigieg, Stuart D. Dowall, Victoria A. Graham

Publikováno v: Human Vaccines & Immunotherapeutics

Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15-70% of reported cases are fatal with no approved vaccine available. In the present study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741d9145a9c831e4310f0f0859a8f440
http://europepmc.org/articles/PMC5049717

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Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques

Autor: Philip Marsh, Arturo Reyes-Sandoval, G. Betts, Ann Williams, Karen E. Gooch, Nick J. Edwards, Sally Sharpe, Laura Sibley, Mike Dennis, Andrew White, Helen McShane, M. W. Carroll

Publikováno v: Clinical and Vaccine Immunology. 20:663-672

Tuberculosis (TB) is a reemerging disease. The only available vaccine,Mycobacterium bovisBCG, is delivered intradermally and confers highly variable efficacy against pulmonary disease. There is an urgent need for improved vaccination strategies. Muri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ed04f8d4dc72961662bfa942cac9a9
https://doi.org/10.1128/cvi.00690-12

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The continued emergence of hantaviruses: isolation of a Seoul virus implicated in human disease, United Kingdom, October 2012

Autor: Lisa J. Jameson, Christopher H. Logue, Sareen E. Galbraith, Barry Atkinson, T Brooks, M W Carroll, N Baker, Roger Hewson

Publikováno v: Scopus-Elsevier

Following a suspected case of hantavirus in a patientsuffering from acute kidney injury, rodents fromthe patient’s property in Yorkshire and the Humber,United Kingdom (UK) were screened for hantaviruses.Hantavirus RNA was detected via RT-PCR in two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13393279550ceab3e420a69e1b226ab
https://doi.org/10.2807/ese.18.01.20344-en

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