Výsledky vyhledávání - "M W Bitensky"

The effect of the γ-subunit of the cyclic GMP phosphodiesterase of bovine and frog (Rana catesbiana) retinal rod outer segments on the kinetic parameters of the enzyme

Autor: Dolores J. Takemoto, M M Whalen, M. W. Bitensky

Publikováno v: Biochemical Journal. 265:655-658

Rod-outer-segment cyclic GMP phosphodiesterase (PDE) (subunit composition alpha beta gamma 2) contains catalytic activity in alpha beta. The gamma-subunits are inhibitors. Removal of the gamma-subunits increases Vmax. without affecting the Km. The in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5a8d7f5b41f5c1f07995063dec2f5b
https://doi.org/10.1042/bj2650655

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The phosphorylation state of phosducin determines its ability to block transducin subunit interactions and inhibit transducin binding to activated rhodopsin

Autor: T, Yoshida, B M, Willardson, J F, Wilkins, G J, Jensen, B D, Thornton, M W, Bitensky

Publikováno v: The Journal of biological chemistry. 269(39)

Heterotrimeric GTP-binding proteins (G-proteins) serve many different signal transduction pathways. Phosducin, a 28-kDa phosphoprotein, is expressed in a variety of mammalian cell types and blocks activation of several classes of G-proteins. Phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ff03db7dcb95e136c6440552e2dd150
https://pubmed.ncbi.nlm.nih.gov/7929057

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Cooperative binding of the retinal rod G-protein, transducin, to light-activated rhodopsin

Autor: B M, Willardson, B, Pou, T, Yoshida, M W, Bitensky

Publikováno v: The Journal of biological chemistry. 268(9)

Direct measurements of the binding between light-activated rhodopsin (Rho*) and transducin, the retinal rod G-protein, revealed a strongly cooperative interaction. Cooperativity was assessed by measuring the association of 125I-labeled transducin (Gt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c6212f6fc0f711a592038017c34b344
https://pubmed.ncbi.nlm.nih.gov/8454608

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Interactions between the subunits of transducin and cyclic GMP phosphodiesterase in Rana catesbiana rod photoreceptors

Autor: A, Yamazaki, F, Hayashi, M, Tatsumi, M W, Bitensky, J S, George

Publikováno v: The Journal of biological chemistry. 265(20)

In bullfrog (Rana catesbiana) rods the activity of cyclic GMP (cGMP) phosphodiesterase was stimulated 10 times by washing disc membranes with an isotonic, GTP-containing buffer. This stimulation was maintained following hydrolysis of GTP and after re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::620675f04297382c836afd17d9f55739
https://pubmed.ncbi.nlm.nih.gov/2164007

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The GTP-binding protein of rod outer segments. I. Role of each subunit in the GTP hydrolytic cycle

Autor: M W Bitensky, D C Torney, Akio Yamazaki, M Tatsumi

Publikováno v: Journal of Biological Chemistry. 262:9316-9323

The GTP-binding protein of Bufo marinus rod outer segments (ROS) is composed of 3 subunits: G alpha, 39,000; G beta, 36,000; and G gamma, approximately 6,500. A stepwise analysis of the GTP hydrolytic cycle (GTP binding, GTP hydrolysis, and GDP relea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e63394c59133624d05db453424b01122
https://doi.org/10.1016/s0021-9258(18)48082-9

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Molecular mechanisms of visual excitation: A concatenation of nonlinear cellular processes

Autor: M. W. Bitensky, J. S. George, A. Yamazaki, Margaret M. Whalen

Publikováno v: Journal of Statistical Physics. 39:513-541

The mechanism of transduction in the photoreceptor remains the least understood link in the chain of molecular and cellular processes that are responsible for vision. This paper reviews the molecular species and processes involved in the absorption o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54fcbe6f4bb48215473915df169ec4cd
https://doi.org/10.1007/bf01008349

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Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye

Autor: Walter Rosenthal, Juan Codina, E J Neer, John D. Hildebrandt, A Yamazaki, M W Bitensky, Lutz Birnbaumer

Publikováno v: Journal of Biological Chemistry. 260:14867-14872

Ns and Ni, the regulatory proteins affecting adenylyl cyclase, and transducin, the guanine nucleotide-binding protein from rod outer segments of the eye, are structurally and functionally related proteins. Of these, the alpha subunits are between 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a67da221a9c9ab4cf9076fcd5813c1e
https://doi.org/10.1016/s0021-9258(17)38653-2

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Metabolism and structure of triacylglycerols in rat epididymal fat pad adipocytes determined by 13C nuclear magnetic resonance

Autor: L O Sillerud, A A Francendese, M W Bitensky, C H Han

Publikováno v: Journal of Biological Chemistry. 261:4380-4388

Carbon-13 nuclear magnetic resonance (NMR) methods have been applied to a study of the structure and metabolism of the triacylglycerols from rat epididymal fat pad adipocytes. Complete NMR signal assignments are provided for adipocytes, the extracted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::273d80eb541d8fb025bc966d5e8ffc2d
https://doi.org/10.1016/s0021-9258(17)38512-5

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Autor: J D, Hildebrandt, J, Codina, W, Rosenthal, L, Birnbaumer, E J, Neer, A, Yamazaki, M W, Bitensky

Publikováno v: The Journal of biological chemistry. 260(27)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e4d53ebc00ced0a71279f0df3502ef8
https://pubmed.ncbi.nlm.nih.gov/3932359

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