Zobrazeno 1 - 6
of 6
pro vyhledávání: '"M W, Teunissen"'
Publikováno v:
Pharmaceutical research. 3(3)
Two model substrates for oxidative hepatic enzyme activity, viz. antipyrine (A) and theophylline (T), were given simultaneously to rats by iv administration. Blood concentrations of A and T were measured by a high-performance liquid chromatographic (
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 233(3)
To nine healthy male volunteers two model substrates for oxidative drug-metabolizing enzyme activity, viz, antipyrine (A) and theophylline (T) were administered simultaneously by the p.o. route. To six of them, the same two drugs were also administer
Publikováno v:
Journal of chromatography. 278(2)
A rapid, selective and sensitive method was developed for the determination of antipyrine and its main metabolites in plasma, saliva and urine by an automated high-performance liquid chromatographic system. Using a MOS-Hypersil reversed-phase column
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 9(6)
The rates of antipyrine and hexobarbital elimination from blood or plasma were used to determine whether the antibiotic rifampicin is an inducer of microsomal oxidative drug metabolism in the pig. Treatment with rifampicin (300 mg, po, twice daily fo
Publikováno v:
European journal of clinical pharmacology. 27(1)
The salivary kinetics and rates of metabolite formation of antipyrine were studied in 6 hyperthyroid and 6 hypothyroid out-patients on 2 occasions, on admission and when T3 and T4 levels had returned to normal after treatment with carbimazole (hypert
Publikováno v:
Pharmacology. 24(3)
Previously published data from this laboratory on the urinary excretion of 3-hydroxymethyl antipyrine (one of the major metabolites of antipyrine in man) have to be reconsidered, because of use of an impure reference substance in the high-pressure li