Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M W, Sereda"'
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
Autor:
R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal, V. Schütza, B. Brügger, C. Lüchtenborg, T. Prukop, J. Stenzel, R. U. Rahman, D. Hermes, D. Ewers, W. Möbius, T. Ruhwedel, I. Katona, J. Weis, D. Klein, R. Martini, W. Brück, W. C. Müller, S. Bonn, I. Bechmann, K. A. Nave, R. M. Stassart, M. W. Sereda
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Charcot–Marie–Tooth disease 1A (CMT1A) is a peripheral demyelinating disease. Here, the authors demonstrate in a rodent model of CMT1A that Schwann cells have impairments in lipid biosynthesis, and that restoring lipids via diet can reverse the d
Externí odkaz:
https://doaj.org/article/8b8e4e83c023447f9c6cbe01a5ec8a8b
Autor:
M W, Sereda
Publikováno v:
Annals of the New York Academy of Sciences. 883
The 'CMT rat': peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22
Autor:
S, Niemann, M W, Sereda, M, Rossner, H, Stewart, U, Suter, H M, Meinck, I R, Griffiths, K A, Nave
Publikováno v:
Annals of the New York Academy of Sciences. 883
We have generated a transgenic rat model of Charcot-Marie-Tooth disease type 1A (CMT1A) providing formal proof that this neuropathy can be caused by increased expression of peripheral myelin protein-22 (PMP22). Heterozygous PMP22-transgenic rats deve