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Effects of peripherally and centrally applied ghrelin in the pathogenesis of ischemia-reperfusion induced injury of the small intestine

Autor: M W, Pawlik, R, Obuchowicz, J, Biernat, W, Szczepanski, R, Pajdo, S, Kwiecień, T, Brzozowski, S J, Konturek, W W, Pawlik

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 62(4)

Ghrelin is an important hormone involved in the control of the human appetite center. Recently, protective properties of this hormone have been recognized in various models of impairment of the gastric mucosa, including stress, ischemia and reperfusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4b58bdda617fd7c6d08875167b22758
https://pubmed.ncbi.nlm.nih.gov/22100844

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Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress

Autor: S, S Kwiecien, M W, Pawlik, T, Brzozowski, P C, Konturek, Z, Sliwowski, W W, Pawlik, S J, Konturek

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 59

Acute gastric mucosal lesions represent an important clinical problem. The experimental model of acute gastritis such as water immersion restraint (WRS) stress is useful tool in examination of pathomechanism of acute gastric damage. Nitric oxide (NO)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44504657d34cbdc35a9e12c8a4115069
https://pubmed.ncbi.nlm.nih.gov/18812632

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Transcriptional upregulation of gastrin in response to peroxisome proliferator-activated receptor gamma agonist triggers cell survival pathways

Autor: A, Ptak-Belowska, M W, Pawlik, G, Krzysiek-Maczka, T, Brzozowski, W W, Pawlik

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 58(4)

Peroxisome proliferator-activated receptor gamma (PPAR gamma) are members of the largest nuclear hormone receptor family of transcription factors (1). PPAR gamma (PPARgamma) plays an important role in adipogenesis, control of sensitivity to insulin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d85248421bd23578f86e936ae1d11ef4
https://pubmed.ncbi.nlm.nih.gov/18195488

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Involvement of sensory afferent fibers and lipid peroxidation in the pathogenesis of stress-induced gastric mucosa damage

Autor: S, Kwiecień, M W, Pawlik, Z, Sliwowski, N, Kwiecień, T, Brzozowski, W W, Pawlik, S J, Konturek

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 58

Ablation of sensory nerves impairs healing of gastric ulcers, but the role of free radicals in the healing process has been little studied. The aim of our present investigations was to determine the participation of reactive oxygen species (ROS) in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::615f6d785d7a8fa3dbb96ecc1b925928
https://pubmed.ncbi.nlm.nih.gov/17901591

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Histamine H3 receptors modulate reactive hyperemia in rat gut

Autor: W W, Pawlik, R, Obuchowicz, M W, Pawlik, R, Sendur, J, Biernat, T, Brzozowski, S J, Konturek

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 55(3)

Reactive hyperemia (RH) is an abrupt blood flow increase following release from mechanical occlusion of an artery, with restoration of intra-arterial pressure. The mechanism of this postocclusion increase in blood flow in the gut is multifactorial. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::840b794acec707e59ce7a940dc521d7d
https://pubmed.ncbi.nlm.nih.gov/15381834

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Gastroprotection by pentoxyfilline against stress-induced gastric damage. Role of lipid peroxidation, antioxidizing enzymes and proinflammatory cytokines

Autor: S, Kwiecień, T, Brzozowski, P C, Konturek, M W, Pawlik, W W, Pawlik, N, Kwiecień, S J, Konturek

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 55(2)

Impairment of blood perfusion in gastric mucosa results in the formation of erosions and ulcers. Nitric oxide (NO), produced via activity of NO-synthase (NOS), appears to be a one of major factors, involved in the regulation of the gastric blood flow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f35365fd80cde9ac00e9f387e8cbd24
https://pubmed.ncbi.nlm.nih.gov/15213357

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Involvement of central and peripheral histamine H(3) receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat

Autor: R, Obuchowicz, M W, Pawlik, T, Brzozowski, S J, Konturek, W W, Pawlik

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 55(1 Pt 2)

Data concerning cardiovascular effects of peripherally and centrally located histamine H(3) receptor stimulation are contradictory, and despite excessive studies their role in the control of the cardiovascular function have not been cleared yet. Effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a8646f5c9c2a3cb5eafc35825eae81b
https://pubmed.ncbi.nlm.nih.gov/15082882

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The role of reactive oxygen species and capsaicin-sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress

Autor: S, Kwiecień, T, Brzozowski, P C, Konturek, M W, Pawlik, W W, Pawlik, N, Kwiecień, S J, Konturek

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 54(3)

Gastric microcirculation plays an important role in the maintenance of the gastric mucosal barrier and mucosal integrity. Sensory nerves are involved in the regulation of mucosal blood circulation and mucosal defense. Therefore, the ablation of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::857a3c18dff9fb6f14e275ea93e7e1e0
https://pubmed.ncbi.nlm.nih.gov/14566080

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