Zobrazeno 1 - 10
of 32
pro vyhledávání: '"M W, Lark"'
Publikováno v:
Biochemical Journal. 312:377-384
Glial hyaluronate-binding protein (GHAP) is a 60 kDa glycoprotein with an amino acid sequence identical to that of the hyaluronate-binding region of versican, a large fibroblast aggregating proteoglycan found in the brain. Both GHAP and versican were
Publikováno v:
Journal of Biological Chemistry. 266:5625-5628
Human recombinant stromelysin-1 was shown to cleave four types of collagen (types II, IX, X, and XI) prepared from bovine and rat cartilages at specific sites. Stromelysin-1 cleaved salt-soluble native molecules of type IX collagen into two main trip
Autor:
A M, Badger, S, Blake, R, Kapadia, S, Sarkar, J, Levin, B A, Swift, S J, Hoffman, G B, Stroup, W H, Miller, M, Gowen, M W, Lark
Publikováno v:
Arthritis and rheumatism. 44(1)
To evaluate the effects of SB 273005, a potent, orally active nonpeptide antagonist of the integrin avbeta3 vitronectin receptor, on joint integrity in rats with adjuvant-induced arthritis (AIA).Male Lewis rats with AIA were orally dosed either proph
Autor:
B J, Votta, J R, White, R A, Dodds, I E, James, J R, Connor, E, Lee-Rykaczewski, C F, Eichman, S, Kumar, M W, Lark, M, Gowen
Publikováno v:
Journal of cellular physiology. 183(2)
We have previously demonstrated that a tartrate-resistant acid phosphatase (TRAP)-positive subpopulation of mononuclear cells isolated from collagenase digests of human osteoclastoma tissue exhibits an osteoclast phenotype and can be induced to resor
Autor:
M W, Lark, G B, Stroup, S M, Hwang, I E, James, D J, Rieman, F H, Drake, J N, Bradbeer, A, Mathur, K F, Erhard, K A, Newlander, S T, Ross, K L, Salyers, B R, Smith, W H, Miller, W F, Huffman, M, Gowen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(2)
The Arg-Gly-Asp (RGD)-binding integrin alpha(V)beta(3) is highly expressed on osteoclasts and has been proposed to mediate cell-matrix adhesion required for osteoclast-mediated bone resorption. Antagonism of this receptor should prevent stable osteoc
Autor:
R D, Kapadia, G B, Stroup, A M, Badger, B, Koller, J M, Levin, R W, Coatney, R A, Dodds, X, Liang, M W, Lark, M, Gowen
Publikováno v:
Technology and health care : official journal of the European Society for Engineering and Medicine. 6(5-6)
There is a tremendous unmet therapeutic need for the treatment of osteoporosis and osteoarthritis. The ovariectomized rat and the guinea pig are widely used animal models for the evaluation of new therapeutics for osteoporosis and osteoarthritis, res
Autor:
A M, Badger, M N, Cook, M W, Lark, T M, Newman-Tarr, B A, Swift, A H, Nelson, F C, Barone, S, Kumar
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(1)
Nitric oxide (NO) is implicated in a number of inflammatory processes and is an important mediator in animal models of rheumatoid arthritis and in in vitro models of cartilage degradation. The pyridinyl imidazole SB 203580 inhibits p38 mitogen-activa
Publikováno v:
La Revue du praticien. 46(6 Spec)
Publikováno v:
Acta orthopaedica Scandinavica. Supplementum. 266
Publikováno v:
Acta orthopaedica Scandinavica. Supplementum. 266