Zobrazeno 1 - 10
of 19
pro vyhledávání: '"M W, Kirschner"'
Publikováno v:
Developmental cell. 1(4)
Vertebrate hairy genes are expressed in patterns thought to be readouts of a "segmentation clock" in the presomitic mesoderm. Here we use transgenic Xenopus embryos to show that two types of regulatory elements are required to reconstitute the segmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::663037eeb64b21213e6127006cc112f5
https://pubmed.ncbi.nlm.nih.gov/11703945
https://pubmed.ncbi.nlm.nih.gov/11703945
Publikováno v:
The Journal of Cell Biology
The wnt pathway regulates the steady state level of beta-catenin, a transcriptional coactivator for the Tcf3/Lef1 family of DNA binding proteins. We demonstrate that Tcf3 can inhibit beta-catenin turnover via its competition with axin and adenomatous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75b7cb3eeff5bd51c97e0c37cb7cf1cc
https://pubmed.ncbi.nlm.nih.gov/11524435
https://pubmed.ncbi.nlm.nih.gov/11524435
Publikováno v:
Molecular cell. 5(3)
Regulation of beta-catenin degradation by intracellular components of the wnt pathway was reconstituted in cytoplasmic extracts of Xenopus eggs and embryos. The ubiquitin-dependent beta-catenin degradation in extracts displays a biochemical requireme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2313819411ea3902654f6b89b5bff98
https://pubmed.ncbi.nlm.nih.gov/10882137
https://pubmed.ncbi.nlm.nih.gov/10882137
Autor:
C M, Pfleger, M W, Kirschner
Publikováno v:
Genesdevelopment. 14(6)
The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and specific. One key component of the degradation system, the anaphase prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25fe5a74aac666b3c4512823345531ef
https://pubmed.ncbi.nlm.nih.gov/10733526
https://pubmed.ncbi.nlm.nih.gov/10733526
Publikováno v:
Nature structural biology. 7(3)
The checkpoint protein Mad2 inhibits the activity of the anaphase promoting complex by sequestering Cdc20 until all chromosomes are aligned at the metaphase plate. We report the solution structure of human Mad2 and its interaction with Cdc20. Mad2 po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e2341c547772f8d342766f8f4daf66f
https://pubmed.ncbi.nlm.nih.gov/10700282
https://pubmed.ncbi.nlm.nih.gov/10700282
Publikováno v:
Science (New York, N.Y.). 277(5328)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe3faea2bd13eeb05ccd9edfc9d0a5fe
https://pubmed.ncbi.nlm.nih.gov/9281074
https://pubmed.ncbi.nlm.nih.gov/9281074
Autor:
K D, Lustig, P T, Stukenberg, T J, McGarry, R W, King, V L, Cryns, P E, Mead, L I, Zon, J, Yuan, M W, Kirschner
Publikováno v:
Methods in enzymology. 283
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b69819721ac0f25b4a459b92223301a1
https://pubmed.ncbi.nlm.nih.gov/9251013
https://pubmed.ncbi.nlm.nih.gov/9251013
Publikováno v:
Neuron. 14(6)
In neurons, tubulin is synthesized only in the cell body or dendrites, yet the growing axon requires a steady supply of this protein at the growth cone. Hence, some mechanism must exist to move tubulin from the cell body to the growth cone. Transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10834afd4507fde053dc0ef31e46689d
https://pubmed.ncbi.nlm.nih.gov/7541635
https://pubmed.ncbi.nlm.nih.gov/7541635
Autor:
M W, Kirschner
Publikováno v:
Important advances in oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::537038da26ccd177430b3f355edb6b96
https://pubmed.ncbi.nlm.nih.gov/1533849
https://pubmed.ncbi.nlm.nih.gov/1533849
Autor:
T L, Hill, M W, Kirschner
Publikováno v:
International review of cytology. 84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d76f93fdc462080209e724f97f7022c
https://pubmed.ncbi.nlm.nih.gov/6358104
https://pubmed.ncbi.nlm.nih.gov/6358104