Zobrazeno 1 - 10
of 114
pro vyhledávání: '"M W, Fox"'
Autor:
Gregory J Crowther, Heidi K Hillesland, Katelyn R Keyloun, Molly C Reid, Maria Jose Lafuente-Monasterio, Sonja Ghidelli-Disse, Stephen E Leonard, Panqing He, Jackson C Jones, Mallory M Krahn, Jack S Mo, Kartheek S Dasari, Anna M W Fox, Markus Boesche, Majida El Bakkouri, Kasey L Rivas, Didier Leroy, Raymond Hui, Gerard Drewes, Dustin J Maly, Wesley C Van Voorhis, Kayode K Ojo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite-
Externí odkaz:
https://doaj.org/article/5e2950d857f248d1802b59df2efcbcbc
Autor:
Wesley C. Van Voorhis, Kayode K. Ojo, Stefan H. I. Kappe, Mark Kennedy, Katelyn R. Keyloun, Steven M. Johnson, Erkang Fan, Tiffany Silver-Brace, Arinjay K. Mitra, Christophe L. M. J. Verlinde, Jen C. C. Hume, Zhongsheng Zhang, Ethan A. Merritt, Anna M. W. Fox, Stephen E. Leonard, Molly C. Reid, Dustin J. Maly, Ryan Choi, Rama Subba Rao Vidadala
Publikováno v:
European Journal of Medicinal Chemistry. 74:562-573
Malaria remains a major health concern for a large percentage of the world's population. While great strides have been made in reducing mortality due to malaria, new strategies and therapies are still needed. Therapies that are capable of blocking th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc5171ac93b64e246ac5a75fba9d705
https://doi.org/10.1016/j.ejmech.2013.12.048
https://doi.org/10.1016/j.ejmech.2013.12.048
Autor:
Claudia Pfander, Kayode K. Ojo, David J. Leibly, Dustin J. Maly, Henning Mann, Charlotte Burstroem, Ryan C. Murphy, Mark Kennedy, Cassie M. Bryan, Steven M. Johnson, Ethan A. Merritt, Stephen N. Hewitt, Natascha Mueller, Oliver Billker, Molly C. Reid, Anna M. W. Fox, Eric T. Larson, Christophe L. M. J. Verlinde, Wesley C. Van Voorhis, Stefan H. I. Kappe
Publikováno v:
Journal of Clinical Investigation; Vol 122
Effective control and eradication of malaria will require new tools to prevent transmission. Current antimalarial therapies targeting the asexual stage of Plasmodium do not prevent transmission of circulating gametocytes from infected humans to mosqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d47a0f0d75061cef960f3c330d4841
Publikováno v:
Zeitschrift für Tierpsychologie. 40:194-209
Developmental changes in the frequency of occurrence of some 23 action patterns were studied in pairs of coyotes, wolves, dogs and their hybrids. Over 4,300 entries were recorded from days 24--42 (85.5 h observations in toto). All subjects showed a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aa91d3f0bc89c6d9526c3235dbeea0
https://doi.org/10.1111/j.1439-0310.1976.tb00932.x
https://doi.org/10.1111/j.1439-0310.1976.tb00932.x
Autor:
Jack S. Mo, Sonja Ghidelli-Disse, Majida El Bakkouri, Gerard Drewes, Mallory M. Krahn, Jackson C. Jones, Kasey Rivas, Katelyn R. Keyloun, Kartheek S. Dasari, Wesley C. Van Voorhis, Maria Jose Lafuente-Monasterio, Stephen E. Leonard, Dustin J. Maly, Panqing He, Kayode K. Ojo, Heidi K. Hillesland, Didier Leroy, Raymond Hui, Gregory J. Crowther, Markus Boesche, Molly C. Reid, Anna M. W. Fox
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d962e31b19a72da100fd049083c828
https://pubmed.ncbi.nlm.nih.gov/26934697
https://pubmed.ncbi.nlm.nih.gov/26934697
Autor:
Yifan Song, Dustin J. Maly, Wesley C. Van Voorhis, Katelyn R. Keyloun, Ryan Choi, Lynn K. Barrett, Ethan A. Merritt, Molly C. Reid, Zhongsheng Zhang, Heidi K. Hillesland, Ramasubbarao Vidadala, Anna M. W. Fox, Erkang Fan, Audrey O.T. Lau, Kayode K. Ojo
Publikováno v:
Parasitology. 141(11)
SUMMARYSpecific roles of individual CDPKs vary, but in general they mediate essential biological functions necessary for parasite survival. A comparative analysis of the structure-activity relationships (SAR) of Neospora caninum, Eimeria tenella and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878079302f6335cabbfcc0eb6105adc9
https://pubmed.ncbi.nlm.nih.gov/24927073
https://pubmed.ncbi.nlm.nih.gov/24927073
Autor:
Richard T. Eastman, Ryan Choi, Nina Isoherranen, Matthew A. Hulverson, Molly C. Reid, Dale J. Kempf, Laura M. Kim, Xin-zhuan Su, Zhongsheng Zhang, Kenneth M. Comess, Mark Kennedy, Dustin J. Maly, Ramasubbarao Vidadala, Anna M. W. Fox, Kayode K. Ojo, Wesley C. Van Voorhis, Stefan H. I. Kappe, Justin D. Lutz, Erkang Fan, Christophe L. M. J. Verlinde, Kasey Rivas
Malaria parasites are transmitted by mosquitoes, and blocking parasite transmission is critical in reducing or eliminating malaria in endemic regions. Here, we report the pharmacological characterization of a new class of malaria transmission-blockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28caa684b36835795d8b35892c63793
https://europepmc.org/articles/PMC3873787/
https://europepmc.org/articles/PMC3873787/
Autor:
M. W. Fox
Publikováno v:
Veterinary Research Communications. 19:9-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7362518dd0c693dd537a548897a3f8
https://doi.org/10.1007/bf01839247
https://doi.org/10.1007/bf01839247
Autor:
Stephen N. Hewitt, Jessica E. Kim, Edward J. Dale, Kayode K. Ojo, Wim G. J. Hol, Steven M. Johnson, Molly C. Reid, Jae Kim, Zhongsheng Zhang, Dustin J. Maly, Ryan C. Murphy, Wesley C. Van Voorhis, Anna M. W. Fox, David J. Leibly, Erkang Fan, Ethan A. Merritt, Christophe L. M. J. Verlinde, B. Gayani K. Perera, Eric T. Larson
Publikováno v:
Journal of medicinal chemistry. 55(6)
Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptosporidium parvum are a major health concern. The life cycle of these parasites is regulated by a family of calcium-dependent protein kinases (CDPKs) that have no direct homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1d315102b951ab390971af8cfed491
https://pubmed.ncbi.nlm.nih.gov/22369268
https://pubmed.ncbi.nlm.nih.gov/22369268
Autor:
Ethan A. Merritt, Amy E. DeRocher, Eric T. Larson, Steven M. Johnson, B. Gayani K. Perera, Erkang Fan, Marilyn Parsons, Ryan C. Murphy, Kayode K. Ojo, Zhongsheng Zhang, Edward J. Dale, Dustin J. Maly, Molly C. Reid, Anna M. W. Fox, Wesley C. Van Voorhis, Panqing He, Natascha Mueller, Jennifer A. Geiger
Publikováno v:
Journal of medicinal chemistry. 55(5)
Toxoplasmosis is a disease of prominent health concern that is caused by the protozoan parasite, Toxoplasma gondii. Proliferation of T. gondii is dependent on its ability to invade host cells, which is mediated, in part, by calcium-dependent protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cc23e4dc6235eea88849412de958db
https://pubmed.ncbi.nlm.nih.gov/22320388
https://pubmed.ncbi.nlm.nih.gov/22320388