Zobrazeno 1 - 10
of 67
pro vyhledávání: '"M W, Dewhirst"'
Publikováno v:
Oncogene. 41:1225-1226
Autor:
M. W. Dewhirst, C.-T. Lee
Publikováno v:
AACR Education book. 2015:19-26
Autor:
G M, Palmer, Z, Tiran, Z, Zhou, M E, Capozzi, W, Park, C, Coletta, A, Pyriochou, Y, Kliger, O, Levy, I, Borukhov, M W, Dewhirst, G, Rotman, J S, Penn, A, Papapetropoulos
Publikováno v:
British journal of pharmacology. 165(6)
Pathological angiogenesis is associated with various human diseases, such as cancer, autoimmune diseases and retinopathy. The angiopoietin (Ang)-Tie2 system plays critical roles in several steps of angiogenic remodelling. Here, we have investigated t
Publikováno v:
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 22(4)
It has been well established that inadequate blood supply combined with high metabolic rates of oxygen consumption results in areas of low oxygen tension (1%) within malignant tumours and that elevating tumour temperatures above 39 degrees Celsius re
Publikováno v:
Photochemistry and photobiology. 74(5)
Photodynamic therapy (PDT) with verteporfin provides a reliable way to destroy malignant tissues. Changes in the blood flow and oxygen partial pressure (pO2) during verteporfin-PDT were studied here in the tumor tissue of the rat mammary R3230Ac carc
Autor:
G M, Tozer, V E, Prise, J, Wilson, M, Cemazar, S, Shan, M W, Dewhirst, P R, Barber, B, Vojnovic, D J, Chaplin
Publikováno v:
Cancer research. 61(17)
The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated in the rat P22 tumor growing in a dorsal skin flap window chamber implanted into BD9 rats. CA-4-P is in clinical trial a
Publikováno v:
Cancer research. 61(7)
The efficacy of novel cancer therapeutics can be hampered by inefficient delivery of agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have be
Autor:
C E, Connor, J D, Norris, G, Broadwater, T M, Willson, M M, Gottardis, M W, Dewhirst, D P, McDonnell
Publikováno v:
Cancer research. 61(7)
Tamoxifen inhibits estrogen receptor (ER) transcriptional activity by competitively inhibiting estradiol binding and inducing conformational changes in the receptor that may prevent its interaction with coactivators. In bone, the cardiovascular syste
Publikováno v:
Cancer research. 61(4)
Elastin-like polypeptides (ELPs) are biopolymers of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly that undergo an inverse temperature phase transition. They are soluble in aqueous solutions below their transition temperature (T1) but hydrophobically co
Publikováno v:
Cancer metastasis reviews. 19(1-2)
Metastasis is the primary cause of mortality in cancer patients. Angiogenesis is intimately involved in metastasis at the site of entry of tumor cells into the vasculature and at the site of eventual metastasis growth. In this commentary, we review c