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Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential interaction coefficients and the local-bulk domain model

Autor: E S, Courtenay, M W, Capp, R M, Saecker, M T, Record

Publikováno v: Proteins.

A denaturant m-value is the magnitude of the slope of a typically linear plot of the unfolding free energy change DeltaG degrees (obs) vs. molar concentration (C(3)) of denaturant. For a given protein, the guanidinium chloride (GuHCl) m-value is appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::756f6c55896eba21d8dfb3f0b468bf27
https://pubmed.ncbi.nlm.nih.gov/11013402

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Wrapping of flanking non-operator DNA in lac repressor-operator complexes: implications for DNA looping

Autor: O V, Tsodikov, R M, Saecker, S E, Melcher, M M, Levandoski, D E, Frank, M W, Capp, M T, Record

Publikováno v: Journal of molecular biology. 294(3)

In our studies of lac repressor tetramer (T)-lac operator (O) interactions, we observed that the presence of extended regions of non-operator DNA flanking a single lac operator sequence embedded in plasmid DNA produced large and unusual cooperative a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ca20fde22c503c4ffaf068c5185b70e
https://pubmed.ncbi.nlm.nih.gov/10610786

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DNA footprints of the two kinetically significant intermediates in formation of an RNA polymerase-promoter open complex: evidence that interactions with start site and downstream DNA induce sequential conformational changes in polymerase and DNA

Autor: M L, Craig, O V, Tsodikov, K L, McQuade, P E, Schlax, M W, Capp, R M, Saecker, M T, Record

Publikováno v: Journal of molecular biology. 283(4)

Kinetic studies of formation and dissociation of open-promoter complexes (RPo) involving Esigma70 RNA polymerase (R) and the lambdaPR promoter (P) demonstrate the existence of two kinetically significant intermediates, designated I1 and I2, and facil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f7889bf1baa77f00523945b840f784e
https://pubmed.ncbi.nlm.nih.gov/9790837

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