Zobrazeno 1 - 10
of 1 241
pro vyhledávání: '"M Valverde"'
Autor:
Meijian Zhang, Emma Barroso, Lucía Peña, Patricia Rada, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117303- (2024)
The role of peroxisome proliferator-activated receptor (PPAR)β/δ in hepatic fibrosis remains a subject of debate. Here, we examined the effects of a PPARβ/δ agonist on the pathogenesis of liver fibrosis and the activation of hepatic stellate cell
Externí odkaz:
https://doaj.org/article/bd3f461a588d498c847ef3d9ba500e5e
Autor:
Patricia Rada, Elena Carceller-López, Ana B. Hitos, Beatriz Gómez-Santos, Constanza Fernández-Hernández, Esther Rey, Julia Pose-Utrilla, Carmelo García-Monzón, Águeda González-Rodríguez, Guadalupe Sabio, Antonia García, Patricia Aspichueta, Teresa Iglesias, Ángela M. Valverde
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102045- (2024)
Objectives: Protein kinase D (PKD) family is emerging as relevant regulator of metabolic homeostasis. However, the precise role of PKD2 in modulating hepatic insulin signaling has not been fully elucidated and it is the aim of this study. Methods: PK
Externí odkaz:
https://doaj.org/article/abf0bce88beb4a23b4cb4540fea29630
Autor:
Demilade Adedinsewo, MD, Jennifer Dugan, BA, Patrick W. Johnson, MS, Erika J. Douglass, DrPH, Andrea Carolina Morales-Lara, MD, Mark A. Parkulo, MD, Henry H. Ting, MD, Leslie T. Cooper, MD, Luis R. Scott, MD, Arturo M. Valverde, MD, Deepak Padmanabhan, MBBS, Nicholas S. Peters, MD, Patrik Bachtiger, MBBS, Mihir Kelshiker, MBBS, Francisco Fernandez-Aviles, MD, Felipe Atienza, MD, Taya V. Glotzer, MD, Marc K. Lahiri, MD, Paari Dominic, MD, Zachi I. Attia, PhD, Suraj Kapa, MD, Peter A. Noseworthy, MD, Naveen L. Pereira, MD, Jessica Cruz, MBA, Elie F. Berbari, MD, Rickey E. Carter, PhD, Paul A. Friedman, MD
Publikováno v:
Mayo Clinic Proceedings: Digital Health, Vol 1, Iss 4, Pp 455-466 (2023)
Objective: To evaluate the ability of a neural network to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using point-of-care electrocardiography obtained with a portable device. Patient and Methods: We enrolled 2827 p
Externí odkaz:
https://doaj.org/article/70df8238488d417d98aee85d5f6a403d
Autor:
Patricia Marañón, Esther Rey, Stephania C. Isaza, Hanghang Wu, Patricia Rada, Carmen Choya-Foces, Antonio Martínez-Ruiz, María Ángeles Martín, Sonia Ramos, Carmelo García-Monzón, Francisco Javier Cubero, Ángela M. Valverde, Águeda González-Rodríguez
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103088- (2024)
Acetaminophen (APAP)-induced liver injury is one of the most prevalent causes of acute liver failure (ALF). We assessed the role of the bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 in APAP-induced hepatotoxicity. The molecular mech
Externí odkaz:
https://doaj.org/article/dfecb0de4ea14159adf701f783671f60
Publikováno v:
European Psychiatry, Vol 67, Pp S533-S533 (2024)
Introduction Depressive disorders represent the main cause of disability in the world, due to its prevalence, its impact on the patient’s quality of life and its role as one of the main risk factors for suicide. Current antidepressant treatments ca
Externí odkaz:
https://doaj.org/article/ea045fe655c4431fa6b11a117d2f3d44
Publikováno v:
European Psychiatry, Vol 67, Pp S433-S433 (2024)
Introduction Manic episodes have a multifactorial etiology, with frequent association with genetic factors, comorbidities such as systemic diseases or secondary to infectious diseases, and environmental exposure factors. The prevalence of bipolar dis
Externí odkaz:
https://doaj.org/article/bd28db19a0ac463e9fed0f1a44003790
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, Maribel Escoll, Daniel Carnicero-Senabre, José Jiménez-Villegas, Ángel J. García-Yagüe, Águeda González-Rodríguez, Irma Garcia-Martinez, Ángela M Valverde, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103027- (2024)
Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease that compromises liver function, for which there is not a specifically approved medicine. Recent research has identified transcription factor NRF2 as a potential therapeutic targe
Externí odkaz:
https://doaj.org/article/55f0658f6cd7407d98a9c86477d2e394
Autor:
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany, Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D. Hammock, Ángela M. Valverde, Xavier Palomer, Carles Galdeano, Santiago Vázquez, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115667- (2023)
Soluble epoxide hydrolase (sEH) is a drug target with the potential for therapeutic utility in the areas of inflammation, neurodegenerative disease, chronic pain, and diabetes, among others. Proteolysis-targeting chimeras (PROTACs) molecules offer ne
Externí odkaz:
https://doaj.org/article/5a58d1a50ea04ea4b20efc84ec133208
Autor:
Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón, Águeda González-Rodríguez
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background & Aims Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A (BMP8A) as a
Externí odkaz:
https://doaj.org/article/8bdf154a44f54c48aa9adb7e918626e3
Autor:
Meijian Zhang, Emma Barroso, Maria Ruart, Lucía Peña, Mona Peyman, David Aguilar-Recarte, Marta Montori-Grau, Patricia Rada, Clara Cugat, Carla Montironi, Mohammad Zarei, Javier Jurado-Aguilar, Antoni Camins, Jesús Balsinde, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115623- (2023)
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)α and β/δ agonist that has reached a phase III clinical trial for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we examined the effec
Externí odkaz:
https://doaj.org/article/482a0be0b5064142a7d350a00b86da03