Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M Val Toledo-Lobo"'
Autor:
Luis G. Guijarro, David Cano-Martínez, M. Val Toledo-Lobo, Lidia Ruiz-Llorente, María Chaparro, Iván Guerra, Marisa Iborra, José Luis Cabriada, Luis Bujanda, Carlos Taxonera, Valle García-Sánchez, Ignacio Marín-Jiménez, Manuel Barreiro-de Acosta, Isabel Vera, María Dolores Martín-Arranz, Francisco Mesonero, Laura Sempere, Fernando Gomollón, Joaquín Hinojosa, Sofía Zoullas, Jorge Monserrat, Cesar Menor-Salvan, Melchor Alvarez-Mon, Javier P. Gisbert, Miguel A. Ortega, Borja Hernández-Breijo
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 727 (2022)
Background: Recently, increased tissue levels of AIF-1 have been shown in experimental colitis, supporting its role in intestinal inflammation. Therefore, we studied the levels of AIF-1 in Crohn’s disease (CD). Methods: This study included 33 patie
Externí odkaz:
https://doaj.org/article/8729a017e24a4e2ca4c8aa824c8777c8
Autor:
Carmen Rubio, Marta Puerto, Juan J. García-Rodríquez, Van B. Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M. Gribble, Frank Reimann, Luis G. Guijarro, Jose M. Carrascosa, Ángela M. Valverde
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Objective: Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays dist
Externí odkaz:
https://doaj.org/article/e20f2ee3c18a474e88809eb466830a96
Autor:
Luis G. Guijarro, Patricia Sanmartin-Salinas, Eva Pérez-Cuevas, M. Val Toledo-Lobo, Jorge Monserrat, Sofia Zoullas, Miguel A. Sáez, Miguel Angel Álvarez-Mon, Julia Bujan, Fernando Noguerales-Fraguas, Eduardo Arilla-Ferreiro, Melchor Álvarez-Mon, Miguel A. Ortega
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 845 (2021)
Actinomycin D (ActD) is an FDA-approved NCI oncology drug that specifically targets and downregulates stem cell transcription factors, which leads to a depletion of stem cells within the tumor bulk. Recently, our research group demonstrated the impor
Externí odkaz:
https://doaj.org/article/18c02be1681b49e4a41af447bc4866e0
Autor:
F. Escrivá, Luis G. Guijarro, David Álvarez-Cilleros, Patricia Sanmartín-Salinas, Carmen Álvarez, M Val Toledo-Lobo, Paula Pérez-Pardo, José M. Carrascosa, Ángela M. Valverde, Esther Lizárraga, María Fernández-Lobato, Carmen Rubio
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Aging in mammals is characterized by failure of the homeostatic mechanisms that regulate energy balance. Several mechanisms have been proposed such as the presence of a low-grade chronic inflammation in different tissues, as well as leptin and insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e109eb8189ab0cbd442e8227a50f5123
https://doi.org/10.1093/gerona/glaa313
https://doi.org/10.1093/gerona/glaa313
Autor:
Jorge Monserrat, Borja Hernández-Breijo, D. Cano-Martínez, Luis G. Guijarro, M Val Toledo-Lobo, Patricia Sanmartín Salinas, Melchor Álvarez-Mon
Publikováno v:
Human Immunology. 81:91-100
We identified the presence of AIF-1 (allograft inflammatory factor-1) in human peripheral blood mononuclear cells (PBMCs) from normal subjects by immunocytological methods. After isolation of different types of mononuclear cells by FACS (Fluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392a340ef6fd6f771000e1a925486ba2
https://doi.org/10.1016/j.humimm.2020.01.011
https://doi.org/10.1016/j.humimm.2020.01.011
Autor:
Miguel A, Ortega, Leonel, Pekarek, Cielo, Garcia-Montero, Oscar, Fraile-Martinez, Miguel A, Saez, Angel, Asúnsolo, Miguel A, Alvarez-Mon, Jorge, Monserrat, Santiago, Coca, M Val, Toledo-Lobo, Natalio, García-Honduvilla, Agustin, Albillos, Julia, Buján, Melchor, Alvarez-Mon, Luis G, Guijarro
Publikováno v:
Histology and histopathology. 37(5)
Pancreatic cancer is a malignancy of rising incidence, especially in developed countries due to causes such as sedentary lifestyles, tobacco smoking and ultraprocessed high fat and high sugar diets, amongst others. It is in fact the 7th cause of canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b592fe3783b5e1b12039df3dace3a69c
https://pubmed.ncbi.nlm.nih.gov/35137378
https://pubmed.ncbi.nlm.nih.gov/35137378
Autor:
Patricia Sanmartín-Salinas, Miguel A Ortega, Melchor Alvarez-Mon, M Val Toledo-Lobo, Eva Pérez-Cuevas, Luis G. Guijarro, Miguel Angel Alvarez-Mon, Miguel A Saez, Fernando Noguerales-Fraguas, Julia Buján, Sofia Zoullas, Eduardo Arilla-Ferreiro, Jorge Monserrat
Publikováno v:
Pharmaceuticals
Volume 14
Issue 9
Pharmaceuticals, Vol 14, Iss 845, p 845 (2021)
Volume 14
Issue 9
Pharmaceuticals, Vol 14, Iss 845, p 845 (2021)
Actinomycin D (ActD) is an FDA-approved NCI oncology drug that specifically targets and downregulates stem cell transcription factors, which leads to a depletion of stem cells within the tumor bulk. Recently, our research group demonstrated the impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63c7883f39da102f0e4682fdf5575a5
https://pubmed.ncbi.nlm.nih.gov/34577545
https://pubmed.ncbi.nlm.nih.gov/34577545
Autor:
Eva M. García-Recio, Marta García-Hernández, Lara Sanz-Criado, Noelia Martínez-Jañez, M Val Toledo-Lobo, M. Elena Martín, M. Isabel Pérez-Morgado, Mercedes García-Villanueva, Celia Pinto-Díez, Isabel Esteban-Rodríguez, Belén Pérez-Mies, Víctor M. González, Silvia Sacristán, Alejandro Pascual
Publikováno v:
Oncotarget
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
MAP kinase interacting kinases (MNKs) modulate the function of oncogene eukaryotic initiation factor 4E (eIF4E) through phosphorylation, which is necessary for oncogenic transformation. MNK1 gives rise to two mRNAs and thus two MNK1 isoforms, named M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f253251d5b271e8df8d24fc30d13fc
http://europepmc.org/articles/PMC5862594
http://europepmc.org/articles/PMC5862594
Autor:
María-Encarnación Fernández-Contreras, Patricia Sanmartín-Salinas, M Val Toledo-Lobo, Luis G. Guijarro, Fernando Noguerales-Fraguas
Publikováno v:
Journal of Molecular Histology. 49:39-49
Insulin receptor substrate-4 (IRS-4), a poorly studied member of the IRS family, may play an important role in colorectal cancer (CRC) tumourigenesis. The aim of this pilot study was to elucidate the potential role of IRS-4 in colorectal carcinogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579f4423bbe76dff2dece0036854f39c
https://doi.org/10.1007/s10735-017-9745-0
https://doi.org/10.1007/s10735-017-9745-0
Autor:
Melchor Alvarez-Mon, Fernando Noguerales-Fraguas, M Val Toledo-Lobo, Jorge Monserrat, Luis G. Guijarro, Miguel A Saez, Miguel A Ortega, Miguel Angel Alvarez-Mon, Julia Buján, Patricia Sanmartín-Salinas, Eva Pérez-Cuevas, Eduardo Arilla-Ferreiro, Sofia Zoullas
Publikováno v:
Cancers
Volume 13
Issue 11
Cancers, Vol 13, Iss 2560, p 2560 (2021)
Volume 13
Issue 11
Cancers, Vol 13, Iss 2560, p 2560 (2021)
New evidence suggests that insulin receptor substrate 4 (IRS-4) may play an important role in the promotion of tumoral growth. In this investigation, we have evaluated the role of IRS-4 in a pilot study performed on patients with liver cancer. We use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6350ba95dbd0c32354da5b499f47d0d
https://doi.org/10.3390/cancers13112560
https://doi.org/10.3390/cancers13112560