Zobrazeno 1 - 7
of 7
pro vyhledávání: '"M V Kindt"'
Publikováno v:
Digestive Diseases and Sciences. 43:1009-1015
Bisphosphonates have generally few clinical adverse effects, the most common being gastrointestinal disturbances. It is generally believed that bisphosphonates with a primary amine are more irritating to the gastrointestinal tract than those without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3420d22a66f9742bc1f084143328facc
https://doi.org/10.1023/a:1018826600877
https://doi.org/10.1023/a:1018826600877
Publikováno v:
Toxicologic Pathology. 23:606-619
L-694,492 (DUP 532), an angiotensin II (AII) receptor antagonist, was given orally at 125 mg/kh/day to rats and monkeys for up to 6 mo to assess the effects of the compound on juxtaglomerular (JG) cells. In rats, mild JG cell hypertrophy/hyperplasia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7198d0c2e10bc6af48cbd3b53992d3a
https://doi.org/10.1177/019262339502300319
https://doi.org/10.1177/019262339502300319
Publikováno v:
Digestive diseases and sciences. 43(5)
Bisphosphonates have generally few clinical adverse effects, the most common being gastrointestinal disturbances. It is generally believed that bisphosphonates with a primary amine are more irritating to the gastrointestinal tract than those without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::483ce96a5bbad11fcb16a7f39f9a3997
https://pubmed.ncbi.nlm.nih.gov/10219829
https://pubmed.ncbi.nlm.nih.gov/10219829
Autor:
Roger C. Duvoisin, Stephen K. Youngster, Arthur Hess, M V Kindt, Patricia K. Sonsalla, Richard E. Heikkila
Publikováno v:
European Journal of Pharmacology. 122:283-287
The administration to mice of 1-methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine (2′-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07affff24fbed5cace53675dfaf7851
https://doi.org/10.1016/0014-2999(86)90115-9
https://doi.org/10.1016/0014-2999(86)90115-9
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 242(3)
1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP) was shown previously to be a more potent neurotoxicant than 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. The present investigation was conducted to determine possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9203ee760b076cb89d0d317260b540bb
https://pubmed.ncbi.nlm.nih.gov/2888874
https://pubmed.ncbi.nlm.nih.gov/2888874
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 242(3)
In previous studies and in the accompanying paper, 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP) was found to be more potent than MPTP in producing dopaminergic neurotoxicity in mice. One purpose of the present study was to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8d34a755add218ae34f5b9a14c586c0
https://pubmed.ncbi.nlm.nih.gov/3498818
https://pubmed.ncbi.nlm.nih.gov/3498818
Publikováno v:
Life sciences. 40(8)
1-Methyl-4-phenylpyridinium (MPP+), the putative toxic metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), inhibited NAD(H)-linked mitochondrial oxidation at the level of Complex I of the electron transport system. MPTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc375da08920be13166f1a65bd215cd
https://pubmed.ncbi.nlm.nih.gov/3100899
https://pubmed.ncbi.nlm.nih.gov/3100899