Zobrazeno 1 - 9 of 9 pro vyhledávání: '"M V Darii"'
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Dimeric bisbenzimidazoles: Cytotoxicity and effects on DNA methylation in normal and cancer human cells
Autor: Vadim N. Tashlitsky, M. V. Darii, Alexander A. Ivanov, A. R. Rakhimova, N. N. Veiko, S. V. Kostyuk, Alexei L. Zhuze, Elizaveta S. Gromova
Publikováno v: Molecular Biology. 47:259-266
Cancer cells are characterized by hypermethylation of the promoter regions of tumor suppressor genes. DNA methyltransferase inhibitors reactivate the genes, pointing to DNA methyltransferases as potential targets for anticancer therapy. Dimeric bisbe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f8fdfe1c50167dfb3ca0cf387e32d18
https://doi.org/10.1134/s0026893313020040
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3
Isolation and site-directed mutagenesis of DNA methyltransferase SssI
Autor: O. V. Kirsanova, Sergey N. Kochetkov, M. V. Darii, Drutsa Vl, Elizaveta S. Gromova
Publikováno v: Molecular Biology. 41:110-117
Prokaryotic DNA methyltransferase SssI (M.SssI) methylates cytosines at C5 in CpG sequences. Bacterial strains that produced M.SssI and its mutants as His6-tagged proteins were constructed. To verify the role of Ser300 in recognizing the CpG sequence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c2e0a038888ac819af7959b55e3138f
https://doi.org/10.1134/s0026893307010153
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4
A new reliable reference gene UBA52 for quantitative real-time polymerase chain reaction studies in pyloric cecal tissues of the starfish Asterias rubens
Autor: A V Snezhkina, L. A. Uroshlev, O. A. Stepanov, Anna S. Speranskaya, Alexey A. Dmitriev, Alexander Kudryavtsev, A O Smurov, O.G. Manylov, M V Darii, Valentina A. Lakunina, Asiya F. Sadritdinova, George S. Krasnov, Anna V. Kudryavtseva, Nataliya V. Melnikova, Maxim S. Belenikin
Publikováno v: Genetics and molecular research : GMR. 13(2)
The starfish Asterias rubens is one of the most abundant echinoderm species in the White, Barents, North, and Baltic Seas. This species is an important component of marine ecosystems and a model object for certain biological studies, in particular th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebc47e94e352b1d16b40d72fc9e9992
https://pubmed.ncbi.nlm.nih.gov/24938608
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5
[Differential expression of genes that encode glycolysis enzymes in kidney and lung cancer in humans]
Autor: A. V. Snezhkina, Alexey A. Dmitriev, V. A. Veselovskii, N. Yu. Oparina, Anna S. Speranskaya, M. V. Darii, A. F. Sadritdinova, O. A. Stepanov, I. M. Barkhatov, Anna V. Kudryavtseva, V. N. Senchenko, Nataliya V. Melnikova
Publikováno v: Genetika. 49(7)
Glycolysis is a main catabolic pathway of glucose metabolism, accompanied by ATP synthesis. More than 30 enzymes are involved in glycolysis, and genes that encode them can be considered housekeeping genes due to the high conservatism and evolutionary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1ac06b5c809c3316d567759d71f3de
https://pubmed.ncbi.nlm.nih.gov/24450150
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7
Dnmt3a-CD is less susceptible to bulky benzo[a]pyrene diol epoxide-derived DNA lesions than prokaryotic DNA methyltransferases
Autor: Vladimir B. Baskunov, Alexander A. Baykov, Alexander Kolbanovskiy, Olga V. Lukashevich, Elizaveta S. Gromova, M. V. Darii
Publikováno v: Biochemistry. 50(5)
Benzo[a]pyrene (B[a]P) is a well-characterized environmental polycyclic aromatic hydrocarbon pollutant. In living organisms, B[a]P is metabolized to the genotoxic anti-benzo[a]pyrene diol epoxide that reacts with cellular DNA to form stereoisomeric a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7223b7b2e446b9986d790f69f2ea61
https://pubmed.ncbi.nlm.nih.gov/21174446
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8
Mutational analysis of the CG recognizing DNA methyltransferase SssI: insight into enzyme-DNA interactions
Autor: Oksana M. Subach, Michèle Reboud-Ravaux, Dominique Deville-Bonne, Krystyna Slaska-Kiss, M. V. Darii, O. V. Kirsanova, Tamás Raskó, Antal Kiss, Natalia A. Cherepanova, Elizaveta S. Gromova
Publikováno v: Biochimica et biophysica acta. 1794(11)
To characterize important steps of DNA methylation by M.SssI, a prokaryotic DNA-(cytosine C5)-methyltransferase (C5-MTase) sharing the specificity of eukaryotic C5-MTases (5'-CG-3'), ten amino acids, selected on the basis of sequence alignments and a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effe6c50cd810c50a2cf2c22ed7a96f7
https://pubmed.ncbi.nlm.nih.gov/19654054
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9
Impact of benzo[a]pyrene-2'-deoxyguanosine lesions on methylation of DNA by SssI and HhaI DNA methyltransferases
Autor: Marina Kolbanovskiy, Radha Bonala, Nicholas E. Geacintov, O. V. Kirsanova, Francis Johnson, Dmitrii A. Alexandrov, Alexander Kolbanovskiy, Vladimir B. Baskunov, Elizaveta S. Gromova, M. V. Darii, D. V. Maltseva, Oksana M. Subach
Publikováno v: Biochemistry. 45(19)
DNA damage caused by the binding of the tumorigen 7R,8S-diol 9S,10R-epoxide (B[a]PDE), a metabolite of bezo[a]pyrene, to guanine in CpG dinucleotide sequences could affect DNA methylation and, thus, represent a potential epigenetic mechanism of chemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad06bfd6b1fb4144ee187dadbdc8b03
https://pubmed.ncbi.nlm.nih.gov/16681387
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