Zobrazeno 1 - 7 of 7 pro vyhledávání: '"M V, Templin"'
1
Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration
Autor: M J, Graham, S T, Crooke, K M, Lemonidis, H J, Gaus, M V, Templin, R M, Crooke
Publikováno v: Biochemical pharmacology. 62(3)
The pharmacokinetics of ISIS 1082, a 21-base heterosequence phosphorothioate oligodeoxynucleotide, were characterized within rodent whole liver, and cellular and subcellular compartments. Cross-species comparisons were performed using Sprague-Dawley
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a89927f3d63fa67f94cd7f8cee6ac339
https://pubmed.ncbi.nlm.nih.gov/11434902
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2
Pharmacokinetics and tissue disposition in monkeys of an antisense oligonucleotide inhibitor of Ha-ras encapsulated in stealth liposomes
Autor: R Z, Yu, R S, Geary, J M, Leeds, T, Watanabe, J R, Fitchett, J E, Matson, R, Mehta, G R, Hardee, M V, Templin, K, Huang, M S, Newman, Y, Quinn, P, Uster, G, Zhu, P K, Working, M, Horner, J, Nelson, A A, Levin
Publikováno v: Pharmaceutical research. 16(8)
This study examined the pharmacokinetics and tissue distribution of an antisense oligonucleotide ISIS 2503, formulated in stealth (pegylated) liposomes (encapsulated) or in phosphate-buffered saline (unencapsulated).Encapsulated or unencapsulated ISI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37e8d81d4c91043ae9cc2463e2cfef90
https://pubmed.ncbi.nlm.nih.gov/10468036
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3
Factors affecting species differences in the kinetics of metabolites of trichloroethylene
Autor: Richard J. Bull, M V Templin, R. D. Stenner, P L Bonate, D Tuman, D.K. Stevens
Publikováno v: Journal of toxicology and environmental health. 44(4)
The hepatocarcinogenicity of trichloroethylene (TRI) in mice has been attributed to a metabolite, trichloroacetate (TCA). Rats of various strains appear to be resistant to TRI-induced hepatocarcinogenesis and produce lower peak concentrations of TCA.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd879f2f24a81680d438ddf9ae74c01
https://pubmed.ncbi.nlm.nih.gov/7723076
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4
Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice
Autor: M V Templin, J C Parker, Richard J. Bull
Publikováno v: Toxicology and applied pharmacology. 123(1)
The hepatocarcinogenicity of trichloroethylene (TRI) has been attributed to the metabolite trichloroacetate (TCA). However, mice also form dichloroacetate (DCA) and trichloroethanol (TCE) as metabolites of TRI. TCA and DCA have both been shown to ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc91d67896670f027b923aec40fbde4c
https://pubmed.ncbi.nlm.nih.gov/8236248
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5
The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene
Autor: Richard J. Bull, J.L. Larson, M V Templin, D.K. Stevens
Publikováno v: Toxicology letters. 68(1-2)
The induction of hepatic tumors in B6C3F1 mice treated with trichloroethylene (TRI) has been attributed to its metabolism to trichloroacetate (TCA). Trichloroacetate is an effective peroxisome proliferator in mice at blood concentrations that are rea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86bd8e72c3b1a291f49c3a438330a8e
https://pubmed.ncbi.nlm.nih.gov/8516764
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