Výsledky vyhledávání - "M V, Pokrovskaya"

Akademický článek

Integration of pedagogical technologies developed for healthy and auditory impaired students

Autor: I. N. Lunina, M. V. Pokrovskaya, E. V. Rezchikova

Publikováno v: Высшее образование в России, Vol 0, Iss 2, Pp 90-95 (2022)

The authors state that in a certain sense the learning problems of different groups of students (healthy and auditory impaired) are similar and can be solved by common pedagogical methods. The article presents the ways of integration of pedagogical t

Externí odkaz: https://doaj.org/article/b331b82cae0e4956b966d480f762d00c

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A Novel L-Asparaginase from Hyperthermophilic Archaeon Thermococcus sibiricus: Heterologous Expression and Characterization for Biotechnology Application

Autor: A. A. Zhgun, Nikolay N. Sokolov, M. V. Pokrovskaya, Dmitry D. Zhdanov, S. S. Aleksandrova, M. V. Dumina, Michael A. Eldarov

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9894, p 9894 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18

L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in medicine and food industry. Drawbacks of current commercial L-ASNases stimulate the search for better-producing sources of the enzyme, and extremophiles are especially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bfa6aea6b8cfce720920676165c9c
https://www.mdpi.com/1422-0067/22/18/9894

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Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors

Autor: Andrea Angeli, Anna A. Plyasova, Claudiu T. Supuran, Nikolay N. Sokolov, D. D. Zhdanov, M. V. Pokrovskaya, Alexander V. Veselovsky, Marta Ferraroni, Abdullah Hilal, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Fabrizio Carta, Emanuela Berrino, Yulia A. Gladilina, Irina I Khan

Publikováno v: Journal of medicinal chemistry. 64(15)

Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3' ends of chromosomes. Since TL-inhibitor (TI) stand-alone cancer therapy has been proven to be remarkably challenging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2c35ca71cc4226b0999557f8ed8828
https://pubmed.ncbi.nlm.nih.gov/34283610

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Effect of Heterologous Expression of Chemotaxis Proteins from Genus Thermotoga on the Growth Kinetics of Escherichia coli Cells

Autor: D. D. Zhdanov, D. V. Grishin, Yu A Gladilina, S. S. Aleksandrova, V A Samoilenko, Nikolay N. Sokolov, M. V. Pokrovskaya, Vadim S. Pokrovsky

Publikováno v: Bulletin of Experimental Biology and Medicine. 167:375-379

In the process of optimization of heterologous expression of thermostable chemotaxis proteins CheW and CheY as industrially useful polypeptides, their direct influence on the cell growth kinetics and morphology of Escherichia coli was observed. CheW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2774d4e60326391fd3077a5a4299f891
https://doi.org/10.1007/s10517-019-04530-z

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D-amino acids in nature, agriculture and biomedicine

Autor: D. V. Grishin, Nikolay N. Sokolov, D. D. Zhdanov, M. V. Pokrovskaya

Publikováno v: All Life. 13:11-22

Information accumulated over the past decades on the physiological functions and metabolic pathways of biosynthesis and degradation of D-amino acids has led to a renewed interest in their study. Th...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a2b13cd1bfad6e2558c701ff9945905
https://doi.org/10.1080/21553769.2019.1622596

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Characteristics of Tumors That Develop in Athymic Mice after Transplantation of Human Malignant CD4+ T-lymphocytes Transformed ex vivo

Autor: Anna A. Plyasova, D. V. Grishin, A. N. Gabasvili, M. V. Pokrovskaya, D. D. Zhdanov, Nikolay N. Sokolov, Yulia A. Gladilina, Vadim S. Pokrovsky, Svetlana S. Alexandrova

Publikováno v: Cell and Tissue Biology. 13:176-187

Normal human CD4+ T-lymphocytes can undergo malignant transformation during prolong cultivation in conditions of high endonuclease G (EndoG) expression or after DNA damage. The aim of this work was to study biochemical and cytogenetic features of tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8460db0c058ee1e7fcf820096a39527
https://doi.org/10.1134/s1990519x19030118

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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis

Autor: D. V. Grishin, D. D. Zhdanov, Yulia A. Gladilina, Nikolay N. Sokolov, Vladimir A. Grachev, Vadim S. Pokrovsky, Anna A. Plyasova, M. V. Pokrovskaya, Svetlana S. Alexandrova, V. S. Orlova

Publikováno v: Biochimie. 157:158-176

Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential regulatory links between endonucleases. Deoxyribonuclease 1 (DNase I) inactivation is caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f37272fb6e25b1207dcc0e2ed2a169a7
https://doi.org/10.1016/j.biochi.2018.11.020

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Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase

Autor: D. D. Zhdanov, Anna A. Plyasova, M. V. Pokrovskaya, Nikolay N. Sokolov, Svetlana S. Alexandrova, Olga M Lisitsyna, Vadim S. Pokrovsky, Abdullah Hilal

Publikováno v: Pharmaceuticals
Pharmaceuticals, Vol 13, Iss 286, p 286 (2020)
Volume 13
Issue 10

The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment. Rhodospirillum rubrum (RrA) has dual mechanism of action and plays a role in the supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667cf7b0a2c5add3f13ba7ddadc38c84
http://europepmc.org/articles/PMC7650658

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Murine regulatory T cells induce death of effector T, B, and NK lymphocytes through a contact-independent mechanism involving telomerase suppression and telomere-associated senescence

Autor: D. V. Grishin, Vladimir A. Grachev, M. V. Pokrovskaya, Nikolay N. Sokolov, D. D. Zhdanov, V. S. Orlova, Svetlana S. Alexandrova, Yulia A. Gladilina, Vadim S. Pokrovsky

Publikováno v: Cellular Immunology. 331:146-160

Regulatory T cells (Tregs) suppress the activity of effector T, B and NK lymphocytes and sustain immunological tolerance, but the proliferative activity of suppressed cells remains unexplored. In the present study, we report that mouse Tregs can indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7041534b99f3b8b49326386e0251fd1
https://doi.org/10.1016/j.cellimm.2018.06.008

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