Výsledky vyhledávání - "M V, Blagosklonny"

Solving puzzles of aging: From disposable soma to signal-transduction pathways

Autor: M. V. Blagosklonny

Publikováno v: Russian Journal of General Chemistry. 80:1407-1414

Aging is believed to be caused by accumulation of unrepaired damage. The repair is believed to be limited by energetic resources. A testable prediction is: the less resources (calorie restriction), the shorter lifespan. In contrast, calorie restricti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::863f831f833974ca250d8cf8d4ebc5f2
https://doi.org/10.1134/s1070363210070364

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

Autor: G, Kroemer, W S, El-Deiry, P, Golstein, M E, Peter, D, Vaux, P, Vandenabeele, B, Zhivotovsky, M V, Blagosklonny, W, Malorni, R A, Knight, M, Piacentini, S, Nagata, G, Melino

Publikováno v: Cell Death & Differentiation. 12:1463-1467

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18d2db70d320885d711015360037e99
https://doi.org/10.1038/sj.cdd.4401724

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Cross-Talk between Protein Kinase C-α (PKC-α) and -δ (PKC-δ): PKC-α Elevates the PKC-δ Protein Level, Altering Its mRNA Transcription and Degradation

Autor: L. Y. Romanova, J. F. Mushinski, I. A. Alexandrov, Richard P. Nordan, M V Blagosklonny

Publikováno v: Biochemistry. 37:5558-5565

Studies utilizing the overexpression of individual isoforms indicated that both PKC-alpha and -delta promote a number of biological effects, including inhibition of DNA synthesis associated with rearrangements of the actin cytoskeleton in the murine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1d4fa0f9086a12fe3b737aae6f9fff8
https://doi.org/10.1021/bi9731807

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Target for cancer therapy: proliferating cells or stem cells

Autor: M V Blagosklonny

Publikováno v: Leukemia. 20(3)

Tumor stem cells are quiescent and, therefore, resistant to therapy, yet harbor the capacity to replenish a tumor after therapy. Therefore, it is tempting to explain all therapeutic failures by the persistence of tumor stem cells. Yet, this explanati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d96bb0c7b9a74d72c1204938fd1cf53
https://pubmed.ncbi.nlm.nih.gov/16357832

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Exploiting cancer cell cycling for selective protection of normal cells

Autor: M V, Blagosklonny, A B, Pardee

Publikováno v: Cancer research. 61(11)

Chemotherapy of cancer is limited by its toxicity to normal cells. On the basis of discoveries in signal transduction and cell cycle regulation, novel mechanism-based therapeutics are being developed. Although these cell cycle modulators were designe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::009bbf3dbecd13b6e9b554b71c49b71d
https://pubmed.ncbi.nlm.nih.gov/11389048

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Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer

Autor: K, Salnikow, M, Costa, W D, Figg, M V, Blagosklonny

Publikováno v: Cancer research. 60(20)

Hypoxia limits tumor growth but selects for higher metastatic potential. We tested the functional activity of hypoxia-inducible factor-1 (HIF-1) in prostate cell lines ranging from normal epithelial cells (PrEC), hormone-dependent LNCaP, hormone-inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9ed2871aed53d084b4e9bec20f51b10
https://pubmed.ncbi.nlm.nih.gov/11059752

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Spotlight on apoptosis. Introduction

Autor: M V, Blagosklonny

Publikováno v: Leukemia. 14(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c31bca1af7ba909dca644896afb42cfc
https://pubmed.ncbi.nlm.nih.gov/10942249

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Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

Autor: S G Hwang, W G An, J B Trepel, M V Blagosklonny

Publikováno v: Leukemia. 14(7)

Inhibitors of proteases are currently emerging as a potential anti-cancer modality. Nonselective protease inhibitors are cytotoxic to leukemia and cancer cell lines and we found that this cytotoxicity is correlated with their potency as inhibitors of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfd3b0dede8735535840303a3cab03d
https://pubmed.ncbi.nlm.nih.gov/10914553

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Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism

Autor: K, Salnikow, W, Su, M V, Blagosklonny, M, Costa

Publikováno v: Cancer research. 60(13)

Nickel (Ni2+) and cobalt (Co2+) mimic hypoxia and were used as a tool to study the role of oxygen sensing and signaling cascades in the regulation of hypoxia-inducible gene expression. These metals can produce oxidative stress; therefore, it was conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aee87ec3488f3019bba58c958cfbcec6
https://pubmed.ncbi.nlm.nih.gov/10910041

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Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells

Autor: M V, Blagosklonny, P C, Bishop, R, Robey, T, Fojo, S E, Bates

Publikováno v: Cancer research. 60(13)

Lack of selectivity in the killing of tumor and normal cells is a major obstacle in cancer therapy. By inhibiting normal but not autonomous cell growth, we exploited the differences in cell cycle regulation to achieve a selective protection of nonaut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b4c9d16b6bb26f07170438c13f9bbd7
https://pubmed.ncbi.nlm.nih.gov/10910051

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