Zobrazeno 1 - 10
of 263
pro vyhledávání: '"M Tokuoka"'
Autor:
Suzumi M. Tokuoka, Fumie Hamano, Ayako Kobayashi, Shungo Adachi, Tomohiro Andou, Tohru Natsume, Yoshiya Oda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were utilized for the proteomic and lipidomic characterization of plasma specimens from patients who developed Alzheimer's disease. Proteomics was performed by both PEA
Externí odkaz:
https://doaj.org/article/99a993a8fa054e32a2a5ef34f10505f9
Autor:
Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M. Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 111940- (2023)
Summary: Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here, we report that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by
Externí odkaz:
https://doaj.org/article/7ee32951ecd74122b19dbf4171b4e0c3
Autor:
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Megumi Honjo, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to no
Externí odkaz:
https://doaj.org/article/3a790bb7932047738f10802992a9fe8f
Autor:
Akinori Nishi, Katsuya Ohbuchi, Noriko Kaifuchi, Chika Shimobori, Hirotaka Kushida, Masahiro Yamamoto, Yoshihiro Kita, Suzumi M. Tokuoka, Ayako Yachie, Yukiko Matsuoka, Hiroaki Kitano
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-6 (2021)
Abstract Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made it possible to analyze multiple metabolites and the associations of individual lipid mediator
Externí odkaz:
https://doaj.org/article/7cb87851d61d409fb44ed690a98dcc1d
Autor:
William J. Valentine, Sherif A. Mostafa, Suzumi M. Tokuoka, Fumie Hamano, Natsuko F. Inagaki, Joel Z. Nordin, Norio Motohashi, Yoshihiro Kita, Yoshitsugu Aoki, Takao Shimizu, Hideo Shindou
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin
Externí odkaz:
https://doaj.org/article/dffd91e077b74473be10610053a34c06
Autor:
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Rei Sakata, Megumi Honjo, Makoto Aihara
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but i
Externí odkaz:
https://doaj.org/article/22ef1f2aa6244fa88337b567288ff18d
Publikováno v:
Metabolites, Vol 12, Iss 4, p 354 (2022)
In targeted metabolomic analysis using liquid chromatography–multiple reaction monitoring–mass spectrometry (LC-MRM-MS), hundreds of MRMs are performed in a single run, yielding a large dataset containing thousands of chromatographic peaks. Autom
Externí odkaz:
https://doaj.org/article/66aeb700869f4082b9e4b322f6df4380
Publikováno v:
Metabolites, Vol 12, Iss 3, p 230 (2022)
Blood samples are minimally invasive and can be collected repeatedly, but they are far from the site of disease and the target molecules are diluted by the large amount of blood. Therefore, we performed lipidomics using immunoprecipitation as a metho
Externí odkaz:
https://doaj.org/article/40039c8e3fbd4554a3fd590a8376c261
Autor:
Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M. Tokuoka, Yoshihiro Kita, Fumie Hamano, Nobuyuki Okahashi, Kazutaka Ikeda, Hiroki Nakanishi, Kosuke Saito, Masami Yokota Hirai, Masaru Yoshida, Yoshiya Oda, Fumio Matsuda, Takeshi Bamba
Publikováno v:
Metabolites, Vol 12, Iss 2, p 135 (2022)
In mass spectrometry-based metabolomics, the differences in the analytical results from different laboratories/machines are an issue to be considered because various types of machines are used in each laboratory. Moreover, the analytical methods are
Externí odkaz:
https://doaj.org/article/8145885c47ea46799181ed43e06d661b
Autor:
William J. Valentine, Suzumi M. Tokuoka, Daisuke Hishikawa, Yoshihiro Kita, Hideo Shindou, Takao Shimizu
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 184-194 (2018)
Adaption of skeletal muscle to endurance exercise includes PPARδ- and AMP-activated protein kinase (AMPK)/PPARγ coactivator 1α-mediated transcriptional responses that result in increased oxidative capacity and conversion of glycolytic to more oxid
Externí odkaz:
https://doaj.org/article/2bfaaa5846584d1ab491fd629828d76f