Zobrazeno 1 - 10
of 56
pro vyhledávání: '"M Todd, Valerius"'
Autor:
Julia Wilflingseder, Michaela Willi, Hye Kyung Lee, Hannes Olauson, Jakub Jankowski, Takaharu Ichimura, Reinhold Erben, M. Todd Valerius, Lothar Hennighausen, Joseph V. Bonventre
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Acute kidney injury is a major health problem amongst hospitalized patients. Here the authors provide a comprehensive characterization of enhancer and super-enhancer elements, and the transcription factor motifs associated with these elements in resp
Externí odkaz:
https://doaj.org/article/6a7aaa51036f4e01a746e663fb07ffcc
Autor:
Min Shi, Kyle W. McCracken, Ankit B. Patel, Weitao Zhang, Lioba Ester, M. Todd Valerius, Joseph V. Bonventre
Publikováno v:
Nature Biotechnology. 41:252-261
Autor:
Andreas Bueckle, Rajeev Malhotra, Sarah A. Teichmann, Yongqun He, Shin Lin, Griffin M. Weber, Marc K. Halushka, Xin Sun, James C. Gee, Hrishikesh Paul, Rebecca T. Beuschel, Sanjay Jain, Maigan A. Brusko, Clive Wasserfall, David Osumi-Sutherland, Teri A. Longacre, Kristen Browne, Amy Bernard, Gloria S. Pryhuber, Yiing Lin, Avinash Boppana, Fiona Ginty, M. Todd Valerius, Jonhan Ho, Katy Börner, Marda Jorgensen, Sujin Lee, Muzlifah Haniffa, John W. Hickey, Jeremy A. Miller, Joel C. Sunshine, Andrea J. Radtke, Ellen M. Quardokus, Laura Jardine, Bruce Herr, Songlin Ding
Publikováno v:
Nature Cell Biology. 23:1117-1128
The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinke
Autor:
Mark E. Williams, Katherine R. Tuttle, Jing Liu, Jinghui Luo, Yougqun He, Laura Pyle, Blue B. Lake, Brad H. Rovin, Lynda Hayashi, Yuguang Xiong, Dennis G. Moledina, Andreas Bueckle, Steven Menez, Glenda V. Roberts, Anand Srivastava, Paul Appelbaum, Heather Ascani, Catherine Campbell, Stephanie M. Grewenow, Mark Aulisio, Jennifer Sun, Christopher R. Anderton, Jamie L. Marshall, Sharon Bledso, John P. Shapiro, Theodore Alexandrov, Richard M. Caprioli, Michele Elder, Leslie Cooperman, Shweta Bansal, Lakeshia Bush, Krzysztof Kiryluk, Mitchell Tublin, Olga G. Troyanskaya, Emilio D. Poggio, Kristina N. Blank, Andrew Janowczyk, Paul Hoover, Sabine M. Diettman, R. Tyler Miller, Katy Borner, Leonidas G. Alexopoulos, James Winters, Anant Madabhushi, Haojia Wu, Chirag R. Parikh, Yumeng Wen, Avi Z. Rosenberg, Agustin Gonzalez-Vicente, Leal Herlitz, Keith Brown, Matthew Gilliam, Joseph P. Gaut, Vidya S. Viswanathan, Karla Mehl, Stewart H. Lecker, Pierre C. Dagher, Dana C. Crawford, Camille Johansen, Anna Greka, Tiffany Shi, Ari Pollack, Renee Frey, Kavya Sharman, Isaac E. Stillman, Stuart J. Shankland, Ricardo Melo Ferreira, Jack Bebiak, Jing Su, Matthias Kretzler, Ellen Palmer, Yury Goltsev, Aaron K. Wong, Matthew R. Rosengart, Taneisha Campbell, Tina Vita, Helmut G. Rennke, Nir Hacohen, Satoru Kudose, Christine Limonte, Kun Zhang, Robyn L. McClelland, Ulysses J. Balis, Katherine J. Kelly, Simon Lee, Ninive C. Conser, Adele Rike, Frederick Dowd, Timothy A. Sutton, Steve Bogen, Petter M. Bjornstad, Zoltan Laszik, Dianbo Zhang, Benjamin D. Humphreys, Pinaki Sarder, Jeffrey M. Spraggins, Ravi Iyengar, Marcelino Rivera, Roy Pinkeney, James C. Williams, Tarek M. El-Achkar, Laura H. Mariani, Richard J. Knight, Manjeri A. Venkatachalam, Pietro A. Canetta, Lloyd G. Cantley, Kayleen Williams, Catherine P. Jayapandian, Edgar A. Otto, Jessica Lukowski, Kassandra Spates-Harden, Ashish Verma, John Saul, Tariq Mukatash, Mia R. Colona, Shana Maikhor, Laurence H. Beck, Titlayo Ilori, Charles E. Alpers, Ellen M. Quardokus, Mujeeb Basit, Dušan Veličković, Raf Van de Plas, Jonathan Himmelfarb, Michael T. Eadon, Chrysta Lienczewski, Christopher Y. Lu, Yijiang M. Chen, Kasra Rezaei, Richard Montellano, Pottumarthi V. Prasad, Francis P. Wilson, Christy Stutzke, Jane Nguyen, Kamalanathan K. Sambandam, Miguel A. Vazquez, Vishal S. Vaidya, Vivette D. D'Agati, Patrick Boada, Adam Wilcox, Astrid Weins, Jennifer A. Schaub, Harold Park, Kumar Sharma, M. Todd Valerius, Stephen Daniel, Sean Eddy, Bruce W. Herr, Kenneth W. Dunn, Jamie Snyder, E. Steve Woodle, Dianna Sendrey, Ljiljana Paša-Tolić, Raghavan Murugan, Brandon Ginley, Bryan Kestenbaum, Celia P. Corona-Villalobos, Olivia Balderes, Sushrut Waikar, Carissa Vinovskis, Brooke Berry, Parmjeet Randhawa, Seth Winfree, Jose R. Torrealba, Ning Shang, Rachel Sealfon, Michael J. Ferkowicz, William S. Bush, Jonas Carson, Robert Koewler, Guanshi Zhang, Robert D. Toto, Ian H. de Boer, Gearoid M. McMahon, Andrew N. Hoofnagle, Vijaykumar R. Kakade, Brendon Lutnick, Melissa M. Shaw, Rita R. Alloway, Rajasree Menon, Afolarin Amodu, Jeanine Basta, Paul J. Lee, Ingrid Onul, Sylvia E. Rosas, Cijang (John) He, Andrew S. Bomback, Yinghua Cheng, Jeffrey B. Hodgin, Samir M. Parikh, Garry Nolan, John A. Kellum, Anil Pillai, Annapurna Pamreddy, Orson W. Moe, Jiten Patel, Jonathan J. Taliercio, S. Susan Hedayati, Anitha Vijayan, Tanima Arora, Evren U. Azeloglu, Paul M. Palevsky, Nathan Heath Patterson, Asra Kermani, Becky Steck, Kavya Anjani, Ashley Berglund, Yashvardhan Jain, Stacey E. Jolly, John R. Sedor, George (Holt) Oliver, Natasha Wen, Nancy Wang, Ruikang Wang, Joseph Ardayfio, Michael Rauchman, Ashley R. Burg, Victoria Blanc, Minnie M. Sarwal, Daniel Hall, Sethu M. Madhavan, Sean D. Mooney, Sushrut S. Waikar, Daria Barwinska, Christopher Y. Park, Tara K. Sigdel, Ugochukwu Ugwuowo, John F. O'Toole, Ragnar Palsson, Insa M. Schmidt, Joel M. Henderson, Hongping Ye, Jens Hansen, Jonathan Barasch, Neil Roy, Nicholas Lucarelli, Anna Shpigel, Ashveena Dighe, Elizabeth Record, Sanjay Jain, Nichole Jefferson
Publikováno v:
Kidney Int
Kidney fibrosis constitutes the shared final pathway of nearly all chronic nephropathies, but biomarkers for the non-invasive assessment of kidney fibrosis are currently not available. To address this, we characterize five candidate biomarkers of kid
Autor:
Ken Hiratsuka, Tomoya Miyoshi, Katharina T. Kroll, Navin R. Gupta, M. Todd Valerius, Thomas Ferrante, Michifumi Yamashita, Jennifer A. Lewis, Ryuji Morizane
Publikováno v:
Science Advances. 8
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease
Autor:
Jens, Hansen, Rachel, Sealfon, Rajasree, Menon, Michael T, Eadon, Blue B, Lake, Becky, Steck, Kavya, Anjani, Samir, Parikh, Tara K, Sigdel, Guanshi, Zhang, Dusan, Velickovic, Daria, Barwinska, Theodore, Alexandrov, Dejan, Dobi, Priyanka, Rashmi, Edgar A, Otto, Miguel, Rivera, Michael P, Rose, Christopher R, Anderton, John P, Shapiro, Annapurna, Pamreddy, Seth, Winfree, Yuguang, Xiong, Yongqun, He, Ian H, de Boer, Jeffrey B, Hodgin, Laura, Barisoni, Abhijit S, Naik, Kumar, Sharma, Minnie M, Sarwal, Kun, Zhang, Jonathan, Himmelfarb, Brad, Rovin, Tarek M, El-Achkar, Zoltan, Laszik, John Cijiang, He, Pierre C, Dagher, M Todd, Valerius, Sanjay, Jain, Lisa M, Satlin, Olga G, Troyanskaya, Matthias, Kretzler, Ravi, Iyengar, Evren U, Azeloglu
Publikováno v:
Science Advances. 8
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of an integrated reference map of cells, pathways, and genes us
Autor:
Hannes Olauson, Lothar Hennighausen, M. Todd Valerius, Julia Wilflingseder, Joseph V. Bonventre, Takaharu Ichimura, Reinhold G. Erben, Hye Kyung Lee, Michaela Willi, Jakub Jankowski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The endogenous repair process can result in recovery after acute kidney injury (AKI) with adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and progressive kidney disease. There is currently limited knowledge ab
Autor:
Bilal A. Naved, Joseph V. Bonventre, Jeffrey A. Hubbell, Neil A. Hukriede, Benjamin D. Humphreys, Carl Kesselman, M. Todd Valerius, Andrew P. McMahon, Stuart J. Shankland, Jason A. Wertheim, Michael J.V. White, Mark P. de Caestecker, Iain A. Drummond
Publikováno v:
Kidney Int
Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction,
Autor:
David Gonzalez-Sanchez, Yutaro Mori, Maria S Chancay, Julia Wilflingseder, Xiaoyan Xiao, Pierre Galichon, Li Li, Kyle W. McCracken, Dario R. Lemos, Joseph V. Bonventre, Takaharu Ichimura, Jake J-K Lee, M. Todd Valerius, Nathan Lee, Elazer R. Edelman, Marian Kalocsay, Diana Tamayo, Ana C Figueroa-Ramirez
Publikováno v:
EMBO Rep
Recent studies demonstrate that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis, however, has been elusive. COUP-TFII (also known as NR2F2) is an import
Autor:
Min, Shi, Kyle W, McCracken, Ankit B, Patel, Weitao, Zhang, Lioba, Ester, M Todd, Valerius, Joseph V, Bonventre
Publikováno v:
Nature biotechnology.
Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe highly efficient, serum-free differentiation of hPSCs into ure