Zobrazeno 1 - 10
of 1 443
pro vyhledávání: '"M Tessier"'
Autor:
E Jacobsohn, Duminda N Wijeysundera, Gerald Lebovic, M Davis, Martine T E Puts, Shabbir M H Alibhai, Karim S Ladha, C Wong, Daniel I McIsaac, C Hanley, T Barnes, G Lorello, N Siddiqui, P Serrano, Tyler R Chesney, S Choi, J Van Vlymen, D Sussman, D Macdonald, P Jüni, Emily Hladkowicz, C David Mazer, M Bosch, CD Mazer, A Jerath, J Pazmino-Canizares, E Kennedy, R Spence, V Lyon, Alice C Wei, Julian F Daza, Sahar Ehtesham, Janet M van Vlymen, DN Wijeysundera, KS Ladha, JF Daza, G Mattina, E Hladkowicz, M Tessier, S Ehtesham, S Nnorom, SMH Alibhai, M Puts, G Lebovic, TR Chesney, AC Wei, S Drozdz, M Louridas, RH Breau, M Lalu, S Abdellatif, S Gagne, E Duceppe, K Zarnke, S Avremescu, D Dumerton, M Karizhenskaia, H El Beheiry, F Bonazza, A Zahavich, M Thorleifson, S L Russell, H Bagry, SY MacDonell, J Dale-Gandar, L Kaustov, A Fleet, S Shaeen, E Al Azazi, M Parotto, S A McCluskey, H Poonawala, D Dillane, Di McIsaac
Publikováno v:
BMJ Open, Vol 12, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/cb9262bd0ed341dd94dacd9c64c0bcb5
Publikováno v:
BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-4 (2024)
Abstract Introduction Adrenoleukodystrophy (ALD) patients exhibit three primary clinical phenotypes: primary adrenal insufficiency, adrenomyeloneuropathy, and cerebral demyelination due to the accumulation of saturated very long-chain fatty acids in
Externí odkaz:
https://doaj.org/article/113e94787ba54bdb882e9bd7ff4620f2
Autor:
Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters, Peter M. Tessier
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTEarly identification of antibody candidates with drug-like properties is essential for simplifying the development of safe and effective antibody therapeutics. For subcutaneous administration, it is important to identify candidates with low s
Externí odkaz:
https://doaj.org/article/36271266403a4691a2dd72e35b369f74
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010160 (2022)
SARS-CoV-2 variants with enhanced transmissibility represent a serious threat to global health. Here we report machine learning models that can predict the impact of receptor-binding domain (RBD) mutations on receptor (ACE2) affinity, which is linked
Externí odkaz:
https://doaj.org/article/6c417fcc7db24638be21640e45224347
Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101101- (2022)
Summary: The generation of high-affinity nanobodies for diverse biomedical applications typically requires immunization or affinity maturation. Here, we report a simple protocol using complementarity-determining region (CDR)-swapping mutagenesis to i
Externí odkaz:
https://doaj.org/article/35b4cd6716784b719aaf0326f1a20c56
Autor:
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitula
Externí odkaz:
https://doaj.org/article/84d23b07351d4847b7e49dca2fbb568c
Autor:
Tanner M. Tessier, Mackenzie J. Dodge, Katelyn M. MacNeil, Andris M. Evans, Martin A. Prusinkiewicz, Joe S. Mymryk
Publikováno v:
Tumour Virus Research, Vol 12, Iss , Pp 200225- (2021)
Papillomaviruses, polyomaviruses and adenoviruses are collectively categorized as the small DNA tumour viruses. Notably, human adenoviruses were the first human viruses demonstrated to be able to cause cancer, albeit in non-human animal models. Despi
Externí odkaz:
https://doaj.org/article/3bccec4ab29e4a019882fa68b5ac6b25
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
There is intense and widespread interest in developing monoclonal antibodies as therapeutic agents to treat diverse human disorders. During early-stage antibody discovery, hundreds to thousands of lead candidates are identified, and those that lack o
Externí odkaz:
https://doaj.org/article/b6bd88b0a74649759d8be0f1d8599c36
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The rapidly evolving nature of antibody drug development has resulted in technologies that generate vast numbers (hundreds to thousands) of lead antibody candidates during early discovery. These candidates must be rapidly pared down to identify the m
Externí odkaz:
https://doaj.org/article/1bd7a94122b74aef990a173a80328531
Autor:
Ghasidit Pornnoppadol, Boya Zhang, Alec A Desai, Anthony Berardi, Henriette A Remmer, Peter M Tessier, Colin F Greineder
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0252558 (2021)
The identification of antibody variable regions in the heavy (VH) and light (VL) chains from hybridomas is necessary for the production of recombinant, sequence-defined monoclonal antibodies (mAbs) and antibody derivatives. This process has received
Externí odkaz:
https://doaj.org/article/2422a6f031f8494c9006d47c01d9a2c4