Zobrazeno 1 - 10
of 125
pro vyhledávání: '"M Teresa García-López"'
Autor:
Paula Pérez-Faginas, M Teresa Aranda, M Teresa García-López, Lourdes Infantes, Asia Fernández-Carvajal, José Manuel González-Ros, Antonio Ferrer-Montiel, Rosario González-Muñiz
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53231 (2013)
1,2-Diamine derivatives are valuable building blocks to heterocyclic compounds and important precursors of biologically relevant compounds. In this respect, amino acid-derived β-keto esters are a suitable starting point for the synthesis of β,γ-di
Externí odkaz:
https://doaj.org/article/7dfdae62614e42498e3fa7f83dc0793c
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4814-4846 (2014)
A series of Phe-Gly dipeptide-derived piperazinones containing an aromatic urea moiety and a basic amino acid has been synthesized and evaluated as inhibitors of human platelet aggregation induced by the PAR1 agonist SFLLRN and as cytotoxic agents in
Externí odkaz:
https://doaj.org/article/3c3b1dc427dc4d95b181225eb599692c
Autor:
M. Teresa García-López, Pilar Ventosa-Andrés, Nikos E. Tsopanoglou, Rosario Herranz, Ioannis Pappos, Ángel M. Valdivielso
Publikováno v:
European Journal of Medicinal Chemistry. 58:98-111
By applying a diversity oriented synthesis strategy for the search of new antagonists of the thrombin receptor PAR1, a series of peptide-based ureas and thioureas, including analogues of the PAR1 reference antagonist RWJ-58259, has been designed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0119d8946a77edba1e464e85b99b33aa
https://doi.org/10.1016/j.ejmech.2012.10.015
https://doi.org/10.1016/j.ejmech.2012.10.015
Synthesis and Regioselective Functionalization of Piperazin-2-ones Based on Phe-Gly Pseudodipeptides
Autor:
M. Teresa García-López, Ángel M. Valdivielso, Pilar Ventosa-Andrés, Marta Gutiérrez-Rodríguez, Rosario Herranz
Publikováno v:
European Journal of Organic Chemistry. 2013:155-161
The synthesis of 1,4-unsubstituted piperazin-2-ones by one-pot reductive cyclization of PheΨ[CH(CN)NH]Gly pseudodipeptides is described. Studies on the reactivity of the piperazin-2-one ring showed a higher reactivity at the N4 position than at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db360903dcd5410720839bc861de975a
https://doi.org/10.1002/ejoc.201201221
https://doi.org/10.1002/ejoc.201201221
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Diverse basic amino acid-derived α-amino nitriles have been synthesized via a modified Strecker reaction, using TMSCN as the cyanide source. It has been found that this synthesis is a slow thermodynamically controlled reaction, where it was difficul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c803d29123174e5abccb0727139e692
https://doi.org/10.1016/j.tetasy.2012.07.009
https://doi.org/10.1016/j.tetasy.2012.07.009
Autor:
M. Angeles Jiménez, Mercedes Martín-Martínez, Samie R. Jaffrey, Rosario González-Muñiz, Clara M. Santiveri, David Andreu, Beatriz G. de la Torre, M. Teresa García-López, Ramiro D. Almeida, Guillermo Gerona-Navarro, José Luis Baeza
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas were designed, synthesized and tested. In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c953f4c98e973cce4f0e25c742aad171
https://doi.org/10.1016/j.bmcl.2011.10.107
https://doi.org/10.1016/j.bmcl.2011.10.107
Autor:
Guillermo Gerona-Navarro, José Luis Baeza, M. Jesús Pérez de Vega, M. Teresa García-López, Mercedes Martín-Martínez, Lourdes Infantes, Kevin Thompson, Rosario González-Muñiz
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
9 pags, 5 figs, 1 tab. -- Supporting Information is available at the Publisher's web
(Chemical Equation Presented) Reverse turns, a common motif in proteins and peptides, have attracted attention due to their relevance in a wide variety of biolo
(Chemical Equation Presented) Reverse turns, a common motif in proteins and peptides, have attracted attention due to their relevance in a wide variety of biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2646c77039cc6b71d9e8a5342072f07f
https://doi.org/10.1021/jo901712x
https://doi.org/10.1021/jo901712x
Autor:
M. Teresa García-López, Rosario González-Muñiz, M. Isabel Garcia‐Aranda, M. Jesús Pérez de Vega
Publikováno v:
European Journal of Organic Chemistry. 2009:4149-4157
Experiments have been performed to prove the applicability and efficacy of 2-nitrobenzenesulfonohydrazide in the on-resin reduction of C=C double bonds of peptide derivatives. The method is useful for the two solid-phase peptide synthesis strategies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a043ccdbc312569ac8c3fb15f64cf4
https://doi.org/10.1002/ejoc.200900363
https://doi.org/10.1002/ejoc.200900363
Publikováno v:
ARKIVOC, Vol 2008, Iss 17, Pp 287-294 (2009)
A significant improvement on the synthesis of the PAR-1 antagonist RWJ-58259 is described, which involves a base-related two-fold yield increase in the indazole N-alkylation, and an easier purification and a nine-fold yield increase in the urea forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7499251ed410340954416b30b0d70bc
https://doi.org/10.3998/ark.5550190.0009.h27
https://doi.org/10.3998/ark.5550190.0009.h27
Autor:
Pilar Ventosa-Andrés, Ángel M. Valdivielso, M. Teresa García-López, Juan A. González-Vera, Rosario Herranz
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9313-9322
The scope of acid-mediated cyclative additions of electrophiles to tryptophan-derived α-amino nitriles for the synthesis of 10 b -substituted-1,2,4,5,10 b ,10 c -hexahydropyrrolo[1′,2′,3′:1,9 a ,9]imidazo[1,2- a ]indoles analogues of indole al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb05548cb976055e5c898c992afcf37
https://doi.org/10.1016/j.bmc.2008.08.070
https://doi.org/10.1016/j.bmc.2008.08.070