Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.

Autor: Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S A Pereira, Gilbert Oliveira Silveira, David da Silva Pires, Sergio Verjovski-Almeida, Frank J Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes-Torres, Dina Robaa, Wolfgang Sippl, Raymond J Pierce, M Teresa Borrello, A Ganesan, Julien Lancelot, Silvana Thiengo, Monica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappié

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008332 (2020)

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ) and, due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent

Externí odkaz: https://doaj.org/article/f432fe7b163b45aa9006ab8d3eb9c2cc

The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma

Autor: Mickenzie Martin, Christopher L. Pin, M. Teresa Borrello

Publikováno v: Paediatrics Publications

Pancreatitis is a debilitating disease involving inflammation and fibrosis of the exocrine pancreas. Recurrent or chronic forms of pancreatitis are a significant risk factor for pancreatic ductal adenocarcinoma. While genetic factors have been identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a97c807d17a4ab9cfa6abc69f959e0f
https://pubmed.ncbi.nlm.nih.gov/34774415

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

Autor: David S. Pires, Monica Ammon Fernandez, Adriana S. A. Pereira, Marcelo Rosado Fantappié, Dante Rotili, A. Ganesan, Eduardo José Lopes Torres, Raymond J. Pierce, Sergio Verjovski-Almeida, Frank J. Dekker, M. Teresa Borrello, Marina de Moraes Mourão, Dina Robaa, Murilo S. Amaral, Isabel Caetano de Abreu da Silva, Amanda Roberta Revoredo Vicentino, Gilbert de Oliveira Silveira, Julien Lancelot, Silvana C. Thiengo, Fernanda Sales Coelho, Antonello Mai, Wolfgang Sippl, Vitor Coutinho Carneiro

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (7), pp.e0008332. ⟨10.1371/journal.pntd.0008332⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008332 (2020)
PLoS Neglected Tropical Diseases, 14(7):0008332, 1-29. PUBLIC LIBRARY SCIENCE
PLoS Neglected Tropical Diseases, 2020, 14 (7), pp.e0008332. ⟨10.1371/journal.pntd.0008332⟩

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ) and, due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dc247d0e79ad2a06cac66b3ba24077
https://pubmed.ncbi.nlm.nih.gov/32609727

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