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Publikováno v:
Journal of Endocrinology. 156:573-581
A proliferative effect of insulin-like growth factor-I (IGF-I) was previously shown in pancreatic islets. However, the mechanism under which IGF-I actions are exerted in insulin-secreting cells is not clear. The rat insulinoma cell line, RINm5F, was
Autor:
Susan C. McKarns, Catherine M. Tally, April D. Lake, Connor E. Bodeman, Nathan J. Cherrington, Anika L. Dzierlenga, Ryan M. Mulligan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 347(1)
Cholestasis results from interrupted bile flow and is associated with immune-mediated liver diseases. It is unclear how inflammation contributes to cholestasis. The aim of this study was to determine whether T and B cells contribute to hepatic transp
Autor:
Martin Schalling, L Grimelius, Amel Guenifi, Christine Carlsson-Skwirut, Sture Falkmer, Anders Höög, M Tally, C.-G. Östenson, A C Sandberg-Nordqvist, Samy M. Abdel-Halim, Vicki R. Sara, Suad Efendic
Publikováno v:
Endocrinology. 137:2415-2423
Insulin-like growth factor II (IGF-II), a member of the insulin family, regulates cell growth and differentiation. The IGF-II gene is localized close to the insulin gene in man and rat. IGF-II peptide binds weakly to the insulin receptor and exerts i
Publikováno v:
Aalborg University
We have previously demonstrated that C-peptide stimulates glucose transport in skeletal muscle from non-diabetic subjects in a dose-dependent manner. To further elucidate the mechanism by which C-peptide activates glucose transport, we investigated t
Autor:
M. Lake, E. Pettersson, M. Tally, M. Granerus, L. Gustafsson, Wilhelm Engström, Paul N. Schofield
Publikováno v:
Reproduction in Domestic Animals. 28:176-181
Autor:
Henrik Wadensten, Mathias Uhlén, E Holmgren, Maris Hartmanis, K Hall, M Tally, Elisabet Samuelsson, B Hammarberg, Tomas Moks
Publikováno v:
Journal of Biological Chemistry. 266:11058-11062
To investigate the biological role of variants of human insulin-like growth factor II (IGF-II), an extended form designated IGF-IIE21, with a molecular mass of 9.8 kDa, was produced in Escherichia coli as a stable and soluble secreted fusion protein.
Autor:
H, Olivecrona, A, Hilding, C, Ekström, H, Barle, B, Nyberg, C, Möller, P J, Delhanty, R C, Baxter, B, Angelin, T J, Ekström, M, Tally
Publikováno v:
The Journal of clinical endocrinology and metabolism. 84(2)
We investigated the acute (4-5 h) and short-term (5 days) effects of GH treatment on hepatic messenger RNA (mRNA) levels of the genes for the insulin-like growth factors (IGFs), insulin-like growth factor binding protein-1, -2, and -3 (IGFBPs), and t
Publikováno v:
International journal of cancer. 69(4)
Plasma levels of IGF-I, IGFBP-I and IGFBP-3 were measured before and during treatment with tamoxifen up to 19+ months in 34 post-menopausal patients with advanced breast cancer. In 28 patients, pro-IGF-IIE (IGF-IIE) levels were determined and IGFBP-3