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Akademický článek

Design of the HEM-POWR study: a prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A

Autor: Johannes Oldenburg, Karina Meijer, Martin Sanabria, María Teresa Álvarez Román, Giancarlo Castaman, Maissaa Janbain, Tadashi Matsushita, Sabine Friedl, M T Reding

Publikováno v: BMJ Open, Vol 11, Iss 9 (2021)

Introduction Haemophilia A is a rare bleeding disorder caused by defects in coagulation factor VIII (FVIII). Damoctocog alfa pegol (BAY 94–9027, Jivi, Bayer, Germany) is a site-specifically PEGylated, extended-half-life, recombinant FVIII, approved

Externí odkaz: https://doaj.org/article/27c7861c02aa44c98351689d40b9cd01

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Inhibitor Development

Autor: J, Astermark, S, Lacroix-Desmazes, M T, Reding

Publikováno v: Haemophilia. 14:36-42

The immune response to factor VIII and the development of inhibitory antibodies is a complex multi-factorial process involving a variety of immune regulatory genes and cells, several of which have the potential to determine risk. A better understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc4a78548bc059241b2a11e5373e53e
https://doi.org/10.1111/j.1365-2516.2008.01711.x

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Patient- and caregiver-reported bleeding symptoms and reasons for starting and stopping treatment with recombinant factor VIIa: analysis of the Dosing Observational Study in Haemophilia (DOSE)

Autor: L A, Valentino, C E, Walsh, M T, Reding, G A, Young, O, Levendoglu-Tugal, D L, Cooper

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 18(4)

Acute haemorrhage treatment in patients with congenital haemophilia with inhibitors (CHwI) has transitioned to home. Patient/caregiver perceptions of bleeding symptoms and reasons for starting/stopping treatment were investigated. Frequently bleeding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc9690ef2789f0f09272a8d260df7fd3
https://pubmed.ncbi.nlm.nih.gov/22348407

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Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia

Autor: A A, Ashrani, M T, Reding, E W, Greeno, A, Shet, N S, Key

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 8(1)

Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19144fc0006f0827cb036b6c034db677
https://pubmed.ncbi.nlm.nih.gov/11886466

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CD4+ T cells specific for factor VIII as a target for specific suppression of inhibitor production

Autor: M T, Reding, H, Wu, M, Krampf, D K, Okita, B M, Diethelm-Okita, N S, Key, B M, Conti-Fine

Publikováno v: Advances in experimental medicine and biology. 489

The studies we reviewed here have begun to clarify the complex cellular mechanisms involved in the immune response to fVIII, and the circumstances under which fVIII inhibitors develop. Further characterization and comparison of the immune response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50859bc96f7919c6f9bd7f12f7cbebe3
https://pubmed.ncbi.nlm.nih.gov/11554586

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Sensitization of CD4+ T cells to coagulation factor VIII: response in congenital and acquired hemophilia patients and in healthy subjects

Autor: M T, Reding, H, Wu, M, Krampf, D K, Okita, B M, Diethelm-Okita, B A, Christie, N S, Key, B M, Conti-Fine

Publikováno v: Thrombosis and haemostasis. 84(4)

Antibodies (Ab) that inhibit factor VIII (fVIII) may develop in patients with hemophilia A and rarely in individuals without congenital fVIII deficiency (acquired hemophilia). Synthesis of fVIII inhibitors requires CD4+ T cells. We investigated the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::477729becad6a8bbaa04bcacd948c88e
https://pubmed.ncbi.nlm.nih.gov/11057864

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