Výsledky vyhledávání

(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes

Autor: J P Condreay, M T Paff, Devron Averett, Lynn D. Condreay, Robert Jansen

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:520-523

The anti-hepatitis B virus (HBV) activity of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) in cultures of primary human hepatocytes was examined. 524W91 was anabolized to the active 5'-triphosphate in these cells. HBV re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa90e76492843fab1540743a472f61e
https://doi.org/10.1128/aac.40.2.520

Zobrazit plný text záznamu

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Autor: Donald J. Nelson, P A Furman, R E Dornsife, Lloyd Frick, D C Liotta, M T Paff, J A Wurster, James A. Fyfe, L J Wilson, Michelle G. Davis

Publikováno v: Antimicrobial Agents and Chemotherapy. 36:2686-2692

The anti-hepatitis B (anti-HBV) activities of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (2'-deoxy-3'-thia-5-fluorocytosine [FTC]) were studied by using an HBV-transfected cell line (HepG2 derivative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db0561b7b0df3d76dc1a55faa69608a
https://doi.org/10.1128/aac.36.12.2686

Zobrazit plný text záznamu

Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol

Autor: H.C. Krasny, R E Dornsife, L R Boone, I Najera, R J Hazen, M Tisdale, Vasu Nair, M H St Clair, J E Reardon, M T Paff

Publikováno v: Antimicrobial agents and chemotherapy. 39(9)

4(S)-(6-Amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol(IsoddA)isthemostantivirallyactivemember of a novel class of optically active isomeric dideoxynucleosides in which the base has been transposed from the natural 1*position to the 2*position and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a839a8c8cd78961445e9bf7c0a8dcd
https://pubmed.ncbi.nlm.nih.gov/8540705

Zobrazit plný text záznamu

2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies

Autor: C U, Lambe, D R, Averett, M T, Paff, J E, Reardon, J G, Wilson, T A, Krenitsky

Publikováno v: Cancer research. 55(15)

Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated human T-leukemic cells. However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d424359a41e495dc6ec35b881092b1e8
https://pubmed.ncbi.nlm.nih.gov/7614470

Zobrazit plný text záznamu

Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model

Autor: Dean W. Selleseth, Susan Mary Daluge, George R. Painter, T F Powdrill, Robert Jansen, M N Ellis, Lance C. Johnson, Lynn D. Condreay, M T Paff, P A Furman

A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbfefafc5a551f2645a7ebcbc2c30cf
https://europepmc.org/articles/PMC284508/

Zobrazit plný text záznamu

Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells

Autor: D J, Fernandes, C, Smith-Nanni, M T, Paff, T A, Neff

Publikováno v: Cancer research. 48(7)

The effects of various antileukemic agents on DNA replication associated with the nuclear matrix were investigated in CCRF-CEM leukemia cells. Residual nuclear matrices were prepared by sequential treatment of nuclei with 1.5 M NaCl, DNase I, and Tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31957c57d388c006646adeab31731152
https://pubmed.ncbi.nlm.nih.gov/3349463

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání