Zobrazeno 1 - 4
of 4
pro vyhledávání: '"M T Harte"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1499:34-48
The adapter molecule CAS is localized primarily within focal adhesions in fibroblasts. Because many of the cellular functions attributed to CAS are likely to be dependent on its presence in focal adhesions, this study was undertaken to identify regio
Publikováno v:
Journal of Biological Chemistry. 271:13649-13655
p130(Cas) (crk associated substrate) has the structural characteristics of an adapter protein, containing multiple consensus SH2 binding sites, an SH3 domain, and a proline-rich domain. The structure of p130(Cas) suggests that it may act to provide a
Publikováno v:
Molecular carcinogenesis. 26(1)
Several lines of evidence indicate that the adapter molecule p130CAS (crk-associated substrate (CAS)) is required for src-mediated cellular transformation. CAS has been shown to be heavily tyrosine-phosphorylated in src-transformed cells, and genetic
Publikováno v:
Oncogene. 12(11)
Adaptor proteins play an important role in signal transduction by regulating the establishment and maintenance of functionally important protein complexes. A recently described member of this group of proteins is p130cas (CAS), which contains numerou