Zobrazeno 1 - 10
of 17
pro vyhledávání: '"M T Audrey Nguyen"'
Autor:
M T Audrey Nguyen, Ai Chen, Wendell J Lu, Wuqiang Fan, Ping-Ping Li, Da Young Oh, David Patsouris
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34976 (2012)
PPARγ plays a key role in adipocyte biology, and Rosiglitazone (Rosi), a thiazolidinedione (TZD)/PPARγ agonist, is a potent insulin-sensitizing agent. Recent evidences demonstrate that adipose tissue inflammation links obesity with insulin resistan
Externí odkaz:
https://doaj.org/article/9fc5f8ecfe134617af6f502b3817415e
Autor:
Steven M. Watkins, Arezou Amidi, Meredith Hawkins, Dorothy D. Sears, Uyenthao Nguyen, Pingping Li, M. T. Audrey Nguyen, Jeffrey E. Pessin, Justin Chapman, Anh Khoi Nguyen, Daorong Feng, Jerrold M. Olefsky, Eun Ju Bae, Min Lu
Publikováno v:
Journal of Biological Chemistry. 285:15333-15345
Obesity represents a state of chronic, low grade inflammation and is associated with infiltration of increased numbers of adipose tissue macrophages (ATMs). Diet-induced obesity leads to an increase in non-inflammatory M1-like ATMs displaying the CD1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08565ce76650b8a5c3ba9e180b100f9a
https://doi.org/10.1074/jbc.m110.100263
https://doi.org/10.1074/jbc.m110.100263
Autor:
Pingping Li, Jaap G. Neels, WuQiang Fan, M. T. Audrey Nguyen, David Patsouris, Jerrold M. Olefsky
Publikováno v:
Journal of Biological Chemistry. 284:31223-31235
The link between intra-abdominal adiposity and type II diabetes has been known for decades, and adipose tissue macrophage (ATM)-associated inflammation has recently been linked to insulin resistance. However, the mechanisms associated with ATM recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d14b066a387bb89cce739c2589d31ef
https://doi.org/10.1074/jbc.m109.041665
https://doi.org/10.1074/jbc.m109.041665
Autor:
Svetlana Favelyukis, M. T. Audrey Nguyen, David Patsouris, Jerrold M. Olefsky, Takeshi Imamura, Wei Liao, Takeshi Yoshizaki, Inder M. Verma
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 293:E219-E227
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in regulating insulin sensitivity and glucose homeostasis. In this study, we identified highly efficient small interfering RNA (siRNA) sequences and used lentiviral s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ba2ecf836297a664a9eb5d176dc520
https://doi.org/10.1152/ajpendo.00695.2006
https://doi.org/10.1152/ajpendo.00695.2006
Autor:
Frank J. Gonzalez, Jerrold M. Olefsky, M. T. Audrey Nguyen, Shankar Subramaniam, Brian Folian, Ho-Yin Leung, Christopher K. Glass, Gautarn Bandyopadyhay, Christopher Benner, Donna Reichart, Mercedes Ricote, Andrea L. Hevener, Matthew J. Watt, Anh-Khoi Nguyen, Mark A. Febbraio
Publikováno v:
Journal of Clinical Investigation. 117:1658-1669
PPAR gamma is required for fat cell development and is the molecular target of antidiabetic thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal muscle, and liver. Unexpectedly, we found that inactivation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddd60327c3e22a5d520b5073fba5ac9
https://doi.org/10.1172/jci31561
https://doi.org/10.1172/jci31561
Autor:
Elizabeth Nelson, M. T. Audrey Nguyen, Gautam Bandyopadhyay, Jerrold M. Olefsky, Jason J. Wilkes
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 289:E1015-E1022
We show that Topiramate (TPM) treatment normalizes whole body insulin sensitivity in high-fat diet (HFD)-fed male Wistar rats. Thus drug treatment markedly lowered glucose and insulin levels during glucose tolerance tests and caused increased insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1171173a6aa2680e8316efacf4a5f5
https://doi.org/10.1152/ajpendo.00169.2005
https://doi.org/10.1152/ajpendo.00169.2005
Autor:
Juan I. Sbodio, Nai-Wen Chi, M. T. Audrey Nguyen, Hiroaki Satoh, Bassil I. Dahiyat, Svetlana Favelyukis, Jonathan Zalevsky, Takeshi Imamura, Jerrold M. Olefsky, Jennie L. Babendure
Publikováno v:
Journal of Biological Chemistry. 280:35361-35371
Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture of free fatty acids (FFAs) to investigate the molecular mechanisms underlying fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc1a52652e23b3084f91769f0a523ab
https://doi.org/10.1074/jbc.m504611200
https://doi.org/10.1074/jbc.m504611200
Autor:
Juan I. Sbodio, Tobias N. Meyer, Tsung Yin J. Yeh, Nai-Wen Chi, Ray M. Lee, M. T. Audrey Nguyen
Publikováno v:
Molecular and Cellular Biochemistry. 276:183-192
Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d705466a82f8a416eb5e2b66bab994
https://doi.org/10.1007/s11010-005-4059-z
https://doi.org/10.1007/s11010-005-4059-z
Autor:
Philipp E. Scherer, Jerrold M. Olefsky, Isao Usui, M. T. Audrey Nguyen, Takeshi Imamura, Maria E. Trujillo, Hiroaki Satoh
Publikováno v:
Diabetes. 54:1304-1313
In this study, we investigated the chronic in vivo effect of adiponectin on insulin sensitivity and glucose metabolism by overexpressing the adiponectin protein in male Wistar rats using intravenous administration of an adenovirus (Adv-Adipo). Virall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694bbfebb74741b9a4a38b4711de4c97
https://doi.org/10.2337/diabetes.54.5.1304
https://doi.org/10.2337/diabetes.54.5.1304
Autor:
Hiroaki Satoh, M. T. Audrey Nguyen, Jerrold M. Olefsky, Philip D.G. Miles, Isao Usui, Takeshi Imamura
Publikováno v:
Journal of Clinical Investigation. 114:224-231
We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism by overexpressing resistin protein in male Wistar rats using intravenous administration of an adenovirus encoding mouse resistin. After 7 days of ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd057baff9bccd1def198ed4e106df1
https://doi.org/10.1172/jci20785
https://doi.org/10.1172/jci20785