Zobrazeno 1 - 10
of 33
pro vyhledávání: '"M TÖrnwall"'
Publikováno v:
British Journal of Pharmacology. 112:13-18
1. Effects of two new inhibitors of catechol O-methylation (CGP 28014 and entacapone; 30 mg kg-1, i.p.) were compared by means of brain microdialysis in rats treated with L-3,4-dihydroxyphenylalanine (L-dopa)/carbidopa (50/50 mg kg-1, i.p., respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2001ae9064eeec02867e6533525ab8ba
https://doi.org/10.1111/j.1476-5381.1994.tb13021.x
https://doi.org/10.1111/j.1476-5381.1994.tb13021.x
Publikováno v:
European Journal of Pharmacology. 239:39-45
The extraneuronal and intraneuronal metabolism of rat brain endogenous dopamine was stimulated by amphetamine (5 mg/kg) and pimozide (2 mg/kg), respectively. Additional metabolic effects of two inhibitors of catechol O-methyltransferase (entacapone a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0859ca19ac603b340b77e1ead6ef2a3a
https://doi.org/10.1016/0014-2999(93)90973-l
https://doi.org/10.1016/0014-2999(93)90973-l
Publikováno v:
Lancet (London, England). 349(9068)
1814 Vol 349 • June 21, 1997 (William E Bunney, Carl W Cotman, Chen Even, Carolyn G Hatalski, W Ian Lipkin, Steven G Potkin, Michelle L Portlance, Mirella Salvatore, Martin Schwemmle); Special Pathogens Branch, Division of viral and Rickettsial Dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46655b7f7cb072b44d98d1e7448cef7
https://pubmed.ncbi.nlm.nih.gov/9269222
https://pubmed.ncbi.nlm.nih.gov/9269222
Publikováno v:
Pharmacologytoxicology. 78(6)
In vivo microdialysis was used to examine the effects of tolcapone (30 mg/kg) on dopamine metabolism in amphetamine (5 mg/kg) and pargyline (75 mg/kg) treated rats. Amphetamine- or pargyline-induced decreases in the extracellular dihydroxyphenyl acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4070ee56a6ef850b184a7030c6e828f1
https://pubmed.ncbi.nlm.nih.gov/8829199
https://pubmed.ncbi.nlm.nih.gov/8829199
Publikováno v:
International journal of clinical pharmacology and therapeutics. 33(9)
Fluconazole, an azole antifungal agent, moderately inhibits the CYP3A-mediated metabolism of midazolam in vitro. We therefore studied whether such an interaction takes place in vivo following oral administration of these drugs, given as relevant doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1331d99171f518171c3e3abb9dd92415
https://pubmed.ncbi.nlm.nih.gov/8520811
https://pubmed.ncbi.nlm.nih.gov/8520811
Autor:
Pekka T. Männistö, M. Törnwall
Publikováno v:
European journal of pharmacology. 250(1)
The effects of three new, selective inhibitors of catechol O-methylation were compared regarding their potentiation of L -3,4-dihydroxyphenylalanine (L-dopa) / carbidopa-induced contralateral circling behaviour in male rats. Some studies were also do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b1adfb8a37a408e07d71a72a5fcddb
https://pubmed.ncbi.nlm.nih.gov/8119326
https://pubmed.ncbi.nlm.nih.gov/8119326
Publikováno v:
Pharmacologytoxicology. 73(3)
Macrolide antibiotics are known to inhibit the metabolism of triazolam and midazolam in vitro and in vivo. To find out if significant interactions take place after single oral doses of these agents to man, 0.25 mg triazolam and 5, 10 and 15 mg of mid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c7483565bdd54e0a57b1d1c5e1faad
https://pubmed.ncbi.nlm.nih.gov/8265524
https://pubmed.ncbi.nlm.nih.gov/8265524
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 320
The effects of three new catechol O-methyltransferase (COMT) inhibitors (nitecapone, entacapone and Ro 41-0960) were assessed on brain neurochemistry and psychomotor tests in levodopa/carbidopa-treated rats and mice. In neurochemical studies in rats,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75eb60100d033e4c582207a9d9525b92
https://pubmed.ncbi.nlm.nih.gov/1300941
https://pubmed.ncbi.nlm.nih.gov/1300941
Autor:
Pekka T. Männistö, M. Törnwall
Publikováno v:
Pharmacologytoxicology. 69(1)
3-Nitropyrocatechols are very potent and selective inhibitors of catechol-O-methyltransferase (COMT). LD50 values of three of these compounds were assessed after intraperitoneal administration with a special emphasis on interactions with drugs increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96af6b47d1f5256015833d7deab8e0a
https://pubmed.ncbi.nlm.nih.gov/1658768
https://pubmed.ncbi.nlm.nih.gov/1658768
Publikováno v:
Journal of neural transmission. Parkinson's disease and dementia section. 2(1)
Interactions between a selective catechol-O-methyltransferase (COMT) inhibitor OR-462 and a monoamine oxidase (MAO)-A inhibitor clorgyline were studied measuring concentrations of L-dopa, dopamine and their metabolites in the rat hypothalamus and str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43101a0ef9db1b4806034fb748082231
https://pubmed.ncbi.nlm.nih.gov/2113389
https://pubmed.ncbi.nlm.nih.gov/2113389