Výsledky vyhledávání

Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro)

Autor: J A, Varner, M T, Nakada, R E, Jordan, B S, Coller

Publikováno v: Angiogenesis. 3(1)

Angiogenesis plays an essential role in the growth and dissemination of solid tumor cancers. The expression of endothelial cell integrin alpha(v)beta3 has been shown to increase during vascular proliferation associated with human tumors. Selective an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cab4f7c19c0f8af2d08e8b23c1447ebf
https://pubmed.ncbi.nlm.nih.gov/14517444

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Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis

Autor: Q, Zhou, M T, Nakada, C, Arnold, K Y, Shieh, F S, Markland

Publikováno v: Angiogenesis. 3(3)

Contortrostatin, a 13.5 kDa disulfide-linked homodimeric polypeptide possessing an Arg-Gly-Asp sequence, was isolated from venom of the southern copperhead snake. Daily injection of contortrostatin into the primary tumor of human breast cancer MDA-MB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5c47666e5551b0dda56d7f2d4ed2fb2
https://pubmed.ncbi.nlm.nih.gov/14517425

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7E3 F(ab')2, an effective antagonist of rat alphaIIbbeta3 and alphavbeta3, blocks in vivo thrombus formation and in vitro angiogenesis

Autor: P M, Sassoli, E L, Emmell, S H, Tam, M, Trikha, Z, Zhou, R E, Jordan, M T, Nakada

Publikováno v: Thrombosis and haemostasis. 85(5)

Abciximab (c7E3 Fab, ReoPro) blocks GPIIb/IIIa and alphavbeta3 and inhibits thrombotic and proliferative events only in humans and non-human primates. The bivalent F(ab')2 fragment is an effective anti-thrombotic agent in canine models. In the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b4db3bf9df34e8bdb13a7fec3da135c
https://pubmed.ncbi.nlm.nih.gov/11372685

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GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole blood

Autor: M I, Furman, L A, Krueger, A L, Frelinger, M R, Barnard, M A, Mascelli, M T, Nakada, A D, Michelson

Publikováno v: Thrombosis and haemostasis. 84(3)

In addition to inhibition of platelet aggregation, GPIIb-IIIa antagonists may reduce thrombotic events via other mechanisms. In a novel whole blood flow cytometric system, we investigated the effects of GPIIb-IIIa antagonists, in the presence or abse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8043a42f49e8b897dfbf51039152b8c
https://pubmed.ncbi.nlm.nih.gov/11019977

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Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor

Autor: D K, Kaul, H M, Tsai, X D, Liu, M T, Nakada, R L, Nagel, B S, Coller

Publikováno v: Blood. 95(2)

Abnormal interaction of sickle red blood cells (SS RBC) with the vascular endothelium has been implicated as a factor in the initiation of vasoocclusion in sickle cell anemia. Both von Willebrand factor (vWf) and thrombospondin (TSP) play important r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::097fcfc188751d153d7448ebab719256
https://pubmed.ncbi.nlm.nih.gov/10627435

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Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation

Autor: M, Christofidou-Solomidou, M T, Nakada, J, Williams, W A, Muller, H M, DeLisser

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(10)

Platelet endothelial cell adhesion molecule-1 (PECAM-1), a member of the Ig superfamily, is found on endothelial cells and neutrophils, and has been shown to be involved in the migration of leukocytes across the endothelium. Although studies have sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dcc3aa227bae52866549d54637d54263
https://pubmed.ncbi.nlm.nih.gov/9144503

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Subtype-selective regulation of beta adrenergic receptor-adenylyl cyclase coupling by phorbol esters in 3T3-L1 fibroblasts

Autor: M T, Nakada, J M, Stadel, S T, Crooke

Publikováno v: The Journal of pharmacology and experimental therapeutics. 253(1)

To study the epigenetic regulation of beta adrenergic receptor subtypes, we examined the effects of phorbol esters on beta adrenergic receptor coupling to adenylyl cyclase in 3T3-L1 fibroblasts, which express both beta-1 and beta-2 adrenergic recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86d12458593d9e186392922a921ce24e
https://pubmed.ncbi.nlm.nih.gov/2158543

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Association between high tumor CCL2 expression and poor survival in patients with resectable pancreatic cancer

Autor: M. DeWitte, Y. Wang, M. T. Nakada, L. Yan, M. R. D'Andrea, Y. Hu, S. Ahrendt, P. Kesavan, Meghan Towers

Publikováno v: Journal of Clinical Oncology. 25:4618-4618

4618 Background: CCL2 (MCP-1) is a chemoattractant protein highly expressed in a variety of cancer types. The expression level of CCL2 has been linked to aggressive disease progression, early dissemination, and poor survival in certain cancers. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45d8e372258bb3d312227750896a2b6f
https://doi.org/10.1200/jco.2007.25.18_suppl.4618

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