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Autor:
A D, Rodrigues, J L, Ferrero, M T, Amann, G A, Rotert, S P, Cepa, B W, Surber, J M, Machinist, N R, Tich, J P, Sullivan, D S, Garvey
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(5)
The metabolism of the cholinergic channel activator [3H]ABT-418 was studied in 9,000g supernatant (S-9) fractions and precision-cut tissue slices prepared from rat, dog, monkey, and human livers. In rat S-9 fractions and tissue slices, the lactam and