Zobrazeno 1 - 10
of 83
pro vyhledávání: '"M Sutak"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 76:314-324
Orphanin FQ (nociceptin, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand at the orphan receptor ORL1, which lacks affinity for opioid receptor ligands. OFQ-like immunoreactivity has been localized in spinal cord areas th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3970a810af5f26157b850df7448e90fc
https://doi.org/10.1139/y98-019
https://doi.org/10.1139/y98-019
Publikováno v:
The Journal of Neuroscience. 16:2342-2351
Tolerance to morphine analgesia is believed to result from a neuronal adaptation produced by continuous drug administration, although the precise mechanisms involved have yet to be established. Recently, we reported selective alterations in rat spina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc5c327eda7044872f5561933ef92b9
https://doi.org/10.1523/jneurosci.16-07-02342.1996
https://doi.org/10.1523/jneurosci.16-07-02342.1996
Publikováno v:
British journal of pharmacology. 155(8)
Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and alpha(2)-adrenoceptors, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f6419dc11e705879d0ee4dc9137e4a5
https://pubmed.ncbi.nlm.nih.gov/18806811
https://pubmed.ncbi.nlm.nih.gov/18806811
Publikováno v:
British journal of pharmacology. 131(5)
This study examined the effects of the peptide CGRP receptor antagonist CGRP(8-37) and the newly-developed non-peptide CGRP receptor antagonist BIBN4096BS for their potential to both inhibit the development and reverse tolerance to the antinociceptiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01818c75abd7e4992350ad236a84ebe4
https://pubmed.ncbi.nlm.nih.gov/11053206
https://pubmed.ncbi.nlm.nih.gov/11053206
Publikováno v:
Neuropeptides. 26:45-46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95387b87880365e4aecb75d84c113a22
https://doi.org/10.1016/0143-4179(94)90248-8
https://doi.org/10.1016/0143-4179(94)90248-8
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 53:540-548
The effect of analgesically active opiate agonists dl-methadone, levorphanol, and their less active forms d-methadone and dextrorphan, respectively, were tested on, (a) the spontaneous release of cortical acetylcholine (ACh) in vivo; (b) the spontane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719324b4e46d4889c8d69a2e768c1c69
https://doi.org/10.1139/y75-076
https://doi.org/10.1139/y75-076
Publikováno v:
Anesthesiology. 62(1)
Clonidine, an alpha 2 adrenergic agonist, has analgesic properties and recently has been used to suppress opiate withdrawal. These two properties theoretically make it a suitable analgesic substitute in patients tolerant to opioids. The objectives of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f9759845a834902a6dc23e73143dc2c
https://pubmed.ncbi.nlm.nih.gov/4038443
https://pubmed.ncbi.nlm.nih.gov/4038443
Publikováno v:
Canadian journal of physiology and pharmacology. 64(3)
The effect of intrathecal injections of dynorphin1-8 (DYN1-8), dynorphin1-13 (DYN1-13), and a putative kappa agonist, U50,488 was tested in the rat tail-flick test. DYN1-8 and DYN1-13 (5, 10, 20 μg) produced a dose-related biphasic antinociceptive r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f0c2f93a2021a4b63783458445a4d4
https://pubmed.ncbi.nlm.nih.gov/2871911
https://pubmed.ncbi.nlm.nih.gov/2871911
Publikováno v:
Canadian journal of physiology and pharmacology. 63(6)
The acute intrathecal (i.t.) administration of 10, 25, 50, and 100 μg morphine and 7.5, 10, 15, and 30 μg (−)norepinephrine (NE) to the rat produced dose-dependent, long-lasting analgesia as assessed by the tail-flick and hot-plate tests. For i.t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4d372c07a3ffcce2de716acc9486d6
https://pubmed.ncbi.nlm.nih.gov/3840055
https://pubmed.ncbi.nlm.nih.gov/3840055
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