NHS Health Check programme: a rapid review update

Autor: K Thompson, F Pearson, J Ling, L Tanner, RPW Kenny, M Still, R Bhardwaj-Gosling

Publikováno v: BMJ Open, Vol 12, Iss 2 (2022)

Externí odkaz: https://doaj.org/article/d48870c117f44d33b1e0bbf6a313ca97

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

Autor: Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool

Publikováno v: Toxins, Vol 13, Iss 5, p 302 (2021)

Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites. However, recent evidence suggests that some ela

Externí odkaz: https://doaj.org/article/db8d99bd5e744e5c9a2b7c1cbd303297

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Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Autor: Chunfang Xie, Laura-Oana Albulescu, Kristina B. M. Still, Julien Slagboom, Yumei Zhao, Zhengjin Jiang, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

Publikováno v: Biomedicines, Vol 8, Iss 6, p 165 (2020)

Phospholipase A2 (PLA2) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA2 i

Externí odkaz: https://doaj.org/article/b55a59bd56e14f879e316a41da2553ad

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib

Autor: Arif Arrahman, Taline D. Kazandjian, Kristina B. M. Still, Julien Slagboom, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

Publikováno v: Toxins, 14(11):736, 1-30. Multidisciplinary Digital Publishing Institute (MDPI)
Arrahman, A, Kazandjian, T D, Still, K B M, Slagboom, J, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2022, ' A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib ', Toxins, vol. 14, no. 11, 736, pp. 1-30 . https://doi.org/10.3390/toxins14110736
Toxins; Volume 14; Issue 11; Pages: 736

Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2bdb8c970520b7204a256941377ad2
https://research.vu.nl/en/publications/af275628-2594-439d-bce5-f412626fac42