Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Autor: Sachel Mok, Adama Gansané, Rithea Leang, Clark H. Cunningham, Romaric Nzoumbou-Boko, David A. Fidock, Aline Uwimana, Ioanna Deni, Nina F. Gnädig, Barbara H. Stokes, Marian Warsame, Kelly Rubiano, Leila S. Ross, Olimatou Kolley, Kurt E. Ward, Issa M. Souleymane, Eric Legrand, Frédéric Ariey, Philip J. Rosenthal, Josefine Striepen, Samuel J. Smith, Abdunoor M. Kabanywanyi, Judith Straimer, Jade Bath, Kyra A Schindler, Didier Menard, Mathieu Ndounga, Tim J. Anderson, François Nosten, Claudette Ndayikunda, Tomas Yeo, Satish K. Dhingra

Publikováno v: eLife, Vol 10 (2021)
eLife
eLife, eLife Sciences Publication, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩
eLife, 2021, 10, pp.e66277. ⟨10.7554/eLife.66277⟩

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d4652f8546d77e0464272dc94dc4b6
https://ora.ox.ac.uk/objects/uuid:24d02c06-c99a-469c-92f8-1d3ccb074394

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

Autor: Tim J. Anderson, Eric Legrand, Samuel J. Smith, Marian Warsame, Kelly Rubiano, Claudette Ndayikunda, Romaric Nzoumbou-Boko, Philip J. Rosenthal, Ioanna Deni, Barbara H. Stokes, Tomas Yeo, Josefine Striepen, Kurt E. Ward, François Nosten, Satish K. Dhingra, Sachel Mok, Leila S. Ross, Aline Uwimana, Clark H. Cunningham, Rithea Leang, Mathieu Ndounga, Issa M. Souleymane, Frédéric Ariey, David A. Fidock, Abdunoor M. Kabanywanyi, Jade Bath, Judith Straimer, Didier Menard, Nina F. Gnädig, Adama Gansané, Olimatou Kolley

The emergence of artemisinin (ART) resistance in Plasmodium falciparum parasites, driven by K13 mutations, has led to widespread antimalarial treatment failure in Southeast Asia. In Africa, our genotyping of 3,299 isolates confirms the emergence of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fa371c484ab5b5a9da57d152378813a
https://doi.org/10.1101/2021.01.27.428390

Cascading effects of elevated ozone on wheat rhizosphere microbial communities depend on temperature and cultivar sensitivity

Autor: F. Changey, Thomas Z. Lerch, M. Souleymane, M. Bagard

Publikováno v: Environmental Pollution
Environmental Pollution, Elsevier, 2018, 242, pp.113-125. ⟨10.1016/j.envpol.2018.06.073⟩

Tropospheric ozone (O3) concentrations have now reached levels that can potentially affect crop production in several regions of the world. The interacting effects of the elevated O3 and temperature on plants are still unclear and their consequences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fed56cd7c405e01507a549644322cb
https://hal.univ-lorraine.fr/hal-03219246

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[Monocular blindness in west Cameroon: epidemiologic aspects and causes]

Autor: M, Moussala, A, Kouda Zeh, M, Souleymane

Publikováno v: Revue internationale du trachome et de pathologie oculaire tropicale et subtropicale et de sante publique : organe de la Ligue contre le trachome avec la collaboration de l'International Organization against Trachoma et des organisation.... 73

The aim of this study was to investigate the epidemiological aspects and causes of unilateral blindness in the western Province of Cameroon. The results show that unilateral blindness affects all ages. This is in contrast with bilateral blindness whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::236221054149e2ece49244545a29bb32
https://pubmed.ncbi.nlm.nih.gov/9889574