Výsledky vyhledávání

Poly(ADP-ribose) polymerase in DNA damage-response pathway: implications for radiation oncology

Publikováno v: International journal of cancer. 90(2)

Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD(+) covalently to itself and other nuclear acceptor proteins. PARP is a zinc finger-containing protein, allowing the enzyme to bind to either d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9855aa7f74845b0af07dcf7470d20d6
https://pubmed.ncbi.nlm.nih.gov/10814955

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Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells

Autor: A H, Boulares, A G, Yakovlev, V, Ivanova, B A, Stoica, G, Wang, S, Iyer, M, Smulson

Publikováno v: The Journal of biological chemistry. 274(33)

An early transient burst of poly(ADP-ribosyl)ation of nuclear proteins was recently shown to be required for apoptosis to proceed in various cell lines (Simbulan-Rosenthal, C., Rosenthal, D., Iyer, S., Boulares, H., and Smulson, M. (1998) J. Biol. Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ed7e164634e84baf07cfe579cad22aa
https://pubmed.ncbi.nlm.nih.gov/10438458

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Detection of heterogeneity of apoptotic fragments of poly (ADP-ribose) polymerase in MDA-MB-468 breast cancer cells: two-dimensional gel analysis

Autor: S C, Prasad, V, Soldatenkov, V, Notario, M, Smulson, A, Dritschilo

Publikováno v: Electrophoresis. 20(3)

Caspace-mediated proteolysis of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) (EC 2.4, 2.30) is a biochemical marker of cell death in response to various apoptotic stimuli. Anti-PARP antibodies identifying the 89 kDa polypeptide from the C-te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd3d15b568c08f999c19ae38724795a7
https://pubmed.ncbi.nlm.nih.gov/10217178

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Deletion of genetic material from a poly(ADP-ribose) polymerase-like gene on chromosome 13 occurs frequently in patients with monoclonal gammopathies

Autor: J, Cao, C H, Hong, L, Rosen, R A, Vescio, M, Smulson, A K, Lichtenstein, J R, Berenson

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 4(7)

Recently, by using a probe for the nuclear DNA repair enzyme poly(ADP-ribose) polymerase gene, a pseudogene was found on the long arm of chromosome 13. RFLP analysis demonstrates the presence of a common "A" allele and a rare "B" allele, which has a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6719fe736c03254fd9ff4bfd4ec951e9
https://pubmed.ncbi.nlm.nih.gov/8672993

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Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts

Autor: Y, Su, D, Rosenthal, M, Smulson, S, Spiegel

Publikováno v: The Journal of biological chemistry. 269(23)

Sphingosine and sphingosine 1-phosphate, metabolites of sphingolipids, stimulate cell proliferation in quiescent Swiss 3T3 fibroblasts and induce transient increases in intracellular free calcium (Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brook

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b24edc42139c866029b0c0c0c91747e
https://pubmed.ncbi.nlm.nih.gov/8206962

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Akademický článek

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Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining

Autor: R, Ding, Y, Pommier, V H, Kang, M, Smulson

Publikováno v: The Journal of biological chemistry. 267(18)

The effects of inducible expression of poly(ADP-ribose) polymerase (PADPRP) antisense RNA in HeLa cells were determined in order to gain further insight into the biological roles of the poly(ADP-ribosyl)ation modification of nuclear proteins. A recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3983b61b9cdf0f35a4141fed58d66fb
https://pubmed.ncbi.nlm.nih.gov/1618781

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Relative predispositional effect of a PADPRP marker allele in B-cell and some non B-cell malignancies

Autor: K, Bhatia, K, Huppi, B, Cherney, M, Raffeld, M, Smulson, I, Magrath

Publikováno v: Current topics in microbiology and immunology. 166

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba53020f600936a0eb508f89c6ee90c6
https://pubmed.ncbi.nlm.nih.gov/1981498

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Kniha

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Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins

Autor: M Smulson, Takashi Sugimura, B Gourlie, V Pigiet, N Malik, Masanao Miwa, A Prieto-Soto

Publikováno v: Journal of Virology. 45:600-606

The host nuclear enzyme poly(ADP-ribose) polymerase has been shown to be associated with the replicative intermediate and mature forms of polyoma virus minichromosomes. Minichromosome-associated histones H2A and H2B as well as several nonhistone prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e04c6fa064722ca27439cd01605354
https://doi.org/10.1128/jvi.45.2.600-606.1983

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