Zobrazeno 1 - 10
of 2 407
pro vyhledávání: '"M Sexton"'
Autor:
Kaleeckal G. Harikumar, Sarah J. Piper, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, Laurence J. Miller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Class B G protein-coupled receptors can form dimeric complexes important for high potency biological effects. Here, we apply pharmacological, biochemical, and biophysical techniques to cells and membranes expressing the prototypic secretin r
Externí odkaz:
https://doaj.org/article/03bd6139abd74708a85a68f98f562b73
Autor:
Kaleeckal G Harikumar, Peishen Zhao, Brian P Cary, Xiaomeng Xu, Aditya J Desai, Maoqing Dong, Jesse I Mobbs, Chirine Toufaily, Sebastian G B Furness, Arthur Christopoulos, Matthew J Belousoff, Denise Wootten, Patrick M Sexton, Laurence J Miller
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002673 (2024)
Development of optimal therapeutics for disease states that can be associated with increased membrane cholesterol requires better molecular understanding of lipid modulation of the drug target. Type 1 cholecystokinin receptor (CCK1R) agonist actions
Externí odkaz:
https://doaj.org/article/897ba52f46f9422aa4eba66be6e9d3a4
Autor:
Yuliantie, Elita, NH Trinh, Phuc, Hick, Caroline, Ebenhoch, Rebecca, Nar, Herbert, Weichert, Dietmar, Christopoulos, Arthur, M Sexton, Patrick, Wootten, Denise
Publikováno v:
In Biochemical Pharmacology November 2024 229
Autor:
Michael D Fetters, William B Ventres, Leslie A Stone, Hamish J Wilson, Sumi M Sexton, David J Doukas, Jessica P Cerdeña, David M Kelley, Jeffrey J Haney, John J Frey
Publikováno v:
Family Medicine and Community Health, Vol 12, Iss Suppl 3 (2024)
Externí odkaz:
https://doaj.org/article/a2841bc53da14636985bed3121609082
Autor:
Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Celine Valant, David M. Thal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The M4 muscarinic acetylcholine receptor (M4 mAChR) has emerged as a drug target of high therapeutic interest due to its expression in regions of the brain involved in the regulation of psychosis, cognition, and addiction. The mAChR agonist,
Externí odkaz:
https://doaj.org/article/7484d1906038449ebf83ab0a1980953a
Autor:
Sarah J. Piper, Giuseppe Deganutti, Jessica Lu, Peishen Zhao, Yi-Lynn Liang, Yao Lu, Madeleine M. Fletcher, Mohammed Akhter Hossain, Arthur Christopoulos, Christopher A. Reynolds, Radostin Danev, Patrick M. Sexton, Denise Wootten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Previously, peptide selectivity in the VPAC receptor family of GPCRs was poorly understood. Here, authors combine cryo-EM and MD data to understand binding and selectivity of VPAC1R and PAC1R peptide agonists that can guide future drug development.
Externí odkaz:
https://doaj.org/article/f2ad6a82f21b446eaee66d37613979d6
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011457 (2023)
The ability of the brain to represent the external world in real-time is impacted by the fact that neural processing takes time. Because neural delays accumulate as information progresses through the visual system, representations encoded at each hie
Externí odkaz:
https://doaj.org/article/df47b1ad14cc42b4a0a59a4ae2c6f658
Autor:
Cassandra L. Falk, Scott M. Sexton
Publikováno v:
INNOVATIONS in Pharmacy, Vol 14, Iss 2 (2023)
Background: Inadequate or inappropriate medication disposal is a public health concern that may lead to increased community risk of accidental poisonings, substance misuse, and environmental pollution. Objective: The study’s primary objective was t
Externí odkaz:
https://doaj.org/article/ca953c627a6f40f9a649d28c15eac88b
Autor:
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J. Belousoff, Hari Venugopal, Tin T. Truong, Alisa Glukhova, Andrew N. Keller, Karen J. Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A. Reynolds, Peishen Zhao, Patrick M. Sexton, Denise Wootten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by
Externí odkaz:
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
Autor:
K. H. Christopher Choy, Jiaqi K. Luo, Cassandra M. J. Wannan, Liliana Laskaris, Antonia Merritt, Warda T. Syeda, Patrick M. Sexton, Arthur Christopoulos, Christos Pantelis, Jess Nithianantharajah
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that shape cognitive processing. Adolescence also represents a vulnerable period for the onset of symptoms in neurode
Externí odkaz:
https://doaj.org/article/00a2aa1f992d47b0a4d2d1e408b01973