Výsledky vyhledávání - "M Schwanstecher"

Ca2+/calmodulin-dependent protein kinase II δ2 regulates gene expression of insulin in INS-1 rat insulinoma cells

Autor: M Schwanstecher, J Seufert, M Möhlig, J Ortmann, A.F.H Pfeiffer, M Osterhoff, H Schatz

Publikováno v: Cell Calcium. 33:175-184

Ca(2+)/calmodulin-dependent protein kinase II is a member of a broad family of ubiquitously expressed Ca(2+) sensing serine/threonine-kinases. Ca(2+)/calmodulin-dependent protein kinase II is highly expressed in insulin secreting cells and is associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcdfb7558ff9f8976564940a184bf4e
https://doi.org/10.1016/s0143-4160(02)00227-0

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Synthesis and evaluation of a glibenclamide glucose-conjugate: a potential new lead compound for substituted glibenclamide derivatives as islet imaging agents

Autor: M. Schwanstecher, C. Schwanstecher, A. Korobeynikov, E. Schirrmacher, H. H. Klein, Sandra Ueberberg, Stephan Schneider, W. Schechinger

Publikováno v: Regulatory peptides. 139(1-3)

The search for novel SUR1-ligands originates from the idea to influence the in vivo behaviour by adding new structural moieties to the glibenclamide structure while preserving its binding affinity. Important application of novel conjugates might be t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081710a937f7edf3ebbb7836bc96cb04
https://pubmed.ncbi.nlm.nih.gov/17222470

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In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans

Publikováno v: Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 113(7)

Pancreatic islet cell mass (PICM) is a major determinant of the insulin secretory capacity in humans. Currently, the only method for accurate assessment of the PICM is an autopsy study. Thus, development of a technique allowing the non-invasive quant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23f1819c9125848658d7d232302d6f6
https://pubmed.ncbi.nlm.nih.gov/16025400

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In-vitro and in-vivo evaluation of [18F]fluorethoxy-bromo-glibenclamide for the non invasive visualisation of the pancreatic islet cell mass in humans using PET

Autor: C. Y. Shiue, M. Schwanstecher, Frank Rösch, H. G. Bucholz, K. Oberholzer, Oliver Thews, Stephan Schneider, Abass Alavi, Ralf Schirrmacher, P. J. Feilen, Matthias M. Weber, Esther Schirrmacher, Mathias Schreckenberger

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 112

In diabetic patients the pancreatic islet cell mass (PICM) is a major determinant of the quantity of insulin that can be secreted. In type 1 diabetic patients the PICM is markedly reduced due to autoimmune destruction of the insulin producing pancrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::809a456fcb6ca74271a9207117e306c1
https://doi.org/10.1055/s-2004-819252

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ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites

Autor: C Schwanstecher, M Schwanstecher, E Markworth

Publikováno v: Diabetes. 49(9)

In pancreatic beta-cells, cytosolic [ATP(4-)] critically controls insulin secretion via inhibition of ATP-sensitive potassium (KATP) channels. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c86b4570703bce0c0378e3362629fd5
https://pubmed.ncbi.nlm.nih.gov/10969823

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