Zobrazeno 1 - 10
of 99
pro vyhledávání: '"M Schoonen"'
Autor:
Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. vanVugt
Publikováno v:
Molecular Oncology, Vol 13, Iss 11, Pp 2422-2440 (2019)
Poly(ADP‐ribose) polymerase (PARP) inhibitors are selectively cytotoxic in cancer cells with defects in homologous recombination (HR) (e.g., due to BRCA1/2 mutations). However, not all HR‐deficient tumors efficiently respond to PARP inhibition an
Externí odkaz:
https://doaj.org/article/6e02b44132fe453cb49c7cb621010ed2
Autor:
Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aid
Externí odkaz:
https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26de
Akademický článek
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Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 1 (2018)
Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibi
Externí odkaz:
https://doaj.org/article/20928cefc07342e184e2c8a2dca9ef00
Autor:
Arkajyoti Bhattacharya, Marieke Everts, Sergi Guerrero Llobet, Rudolf S N Fehrmann, Pepijn M Schoonen, Marcel A. T. M. van Vugt, Nathalie van den Tempel, Yannick P Kok
Publikováno v:
Oncogenesis, Vol 9, Iss 10, Pp 1-15 (2020)
Oncogenesis, 9(10):88. Nature Publishing Group
Oncogenesis
Oncogenesis, 9(10):88. Nature Publishing Group
Oncogenesis
Oncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high levels of replication stress, tumors depend on pathways to deal with these DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a3cca2f6a1dedeee0c223671bd90ed
http://link.springer.com/article/10.1038/s41389-020-00270-2
http://link.springer.com/article/10.1038/s41389-020-00270-2
Autor:
G Offiah, C Kennedy, C O’Connor, M Schoonen, P O’Connor, Kausik K. Ray, J Gallagher, Brendan McAdam, Vincent Maher
Publikováno v:
Oral abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f4b987b9471eaa140a0f0cad64ad78f
https://doi.org/10.1136/heartjnl-2021-ics.14
https://doi.org/10.1136/heartjnl-2021-ics.14
Publikováno v:
Animal Genetics. 50:764-767
The genus Agapornis, or lovebirds, are popular pet parrots worldwide. Currently, breeders are dependent on pedigree records as a selection tool as no molecular parentage verification test is available for any of the nine species. The A. roseicollis r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa671f1d78efbba815949f0580937aed
https://doi.org/10.1111/age.12859
https://doi.org/10.1111/age.12859
Autor:
Yannick P Kok, Floris Foijer, Bjorn Bakker, Elles Wierenga, Diana C.J. Spierings, Marcel A. T. M. van Vugt, Pepijn M Schoonen
Publikováno v:
Molecular oncology. Wiley
Molecular Oncology
Molecular Oncology, Vol 13, Iss 11, Pp 2422-2440 (2019)
Molecular Oncology
Molecular Oncology, Vol 13, Iss 11, Pp 2422-2440 (2019)
Poly(ADP-ribose) polymerase (PARP) inhibitors are selectively cytotoxic in cancer cells with defects in homologous recombination (HR) (e.g., due to BRCA1/2 mutations). However, not all HR-deficient tumors efficiently respond to PARP inhibition and of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a987cedf9bf3600ada2730c222255d9d
https://research.rug.nl/en/publications/64ea2723-21a2-4aa8-bb66-b9fc93300102
https://research.rug.nl/en/publications/64ea2723-21a2-4aa8-bb66-b9fc93300102
Autor:
Eric Bruckert, M Sibartie, B. van Hout, I Bridges, M Schoonen, Kausik K. Ray, Lieven Annemans
Publikováno v:
European Heart Journal. 40
Background FH is a genetic disorder which causes lifelong elevations in LDL-C from birth, resulting in a significantly increased risk of premature atherosclerotic cardiovascular disease (ASCVD). In clinical trials among patients with heterozygous FH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7351896fba795c596ce72e32b443d871
https://doi.org/10.1093/eurheartj/ehz747.0261
https://doi.org/10.1093/eurheartj/ehz747.0261
Publikováno v:
Advances in protein chemistry and structural biology. 115
Genomically instable cancers are characterized by progressive loss and gain of chromosomal fragments, and the acquisition of complex genomic rearrangements. Such cancers, including triple-negative breast cancers and high-grade serous ovarian cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ceb1874ad38f91a2f8a06e18fe5a19b
https://pubmed.ncbi.nlm.nih.gov/30798931
https://pubmed.ncbi.nlm.nih.gov/30798931