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Autor:
K. Winkler, G. Beron, R. Kotz, M. Salzer-Kuntschik, J. Beck, W. Beck, W. Brandeis, W. Ebell, R. Erttmann, U. Göbel, W. Havers, G. Henze, L. Hinderfeld, P. Höcker, A. Jobke, H. Jürgens, H. Kabisch, P. Preusser, G. Prindull, W. Ramach, J. Ritter, J. Sekera, J. Treuner, G. Wüst
Publikováno v:
Zeitschrift für Orthopädie und ihre Grenzgebiete. 124:22-29
Following preoperative chemotherapy of 9-18 weeks duration limb salvage procedures were performed instead of ablative surgery in about 1/2 of the patients (pts). Overall continuous disease-free survival rate is 69% (80/115) at 37 (21-51) months. 5 pt
Autor:
Rainer Kotz, M. Salzer-Kuntschik, A. R. von Hochstetter, Volker Ewerbeck, N. Münchow, G. U. Exner, U. Heise, D. Schwenzer, Ulrich Göbel, K. Helmke, Rainer Maas, Jörn Treuner, M. Werner, Heribert Jürgens, Stefan S. Bielack, N. Fuchs, Norbert Graf, Günter Delling, U. Veltmann, T. Birkfellner, Andreas Zoubek, Beate Kempf-Bielack, W. Winkelmann
Publikováno v:
Klinische Pädiatrie. 211:260-270
BACKGROUND Owing to twenty years of multicentric interdisciplinary cooperation, the COSS group has been able to collect data on a large group of osteosarcoma patients treated by neoadjuvant therapy. This paper reviews results achieved in patients wit
Autor:
A Zoubek, C Pfleiderer, M Salzer-Kuntschik, G Amann, R Windhager, FM Fink, E Koscielniak, O Delattre, S Strehl, PF Ambros, H Gadner, H Kovar
Publikováno v:
British Journal of Cancer
Ewing tumours (ET), including Ewing's sarcoma and peripheral primitive neuroectodermal tumour, are well characterised at the molecular level by a unique chromosomal rearrangement which fuses the EWS gene to one of two closely related ETS proto-oncoge
Autor:
H. Kovar, A. Zoubek, C. Pfleiderer, G. Jug, A. Auinger, D. Aryee, P. Ambros, M. Salzer-Kuntschik, G. Amann, R. Windhager, H. Gadner
Publikováno v:
Klinische Pädiatrie. 206:196-200
The family of Ewing tumors (ET) is characterised by a unique gene rearrangement which is represented by a translocation t(11;22) (q24;q12) or a deletion del 22q12 in most cytogenetically analysable cases. The recent cloning of the underlying gene fus
Autor:
P. Bieling, S. Bielack, G. Delling, H. Jürgens, R. Kotz, C. Dose, H. Astheimer, G. Exner, H. Gadner, N. Graf, J. Ritter, M. Salzer-Kuntschik, P. Weinel, K. Winkler
Publikováno v:
Klinische Pädiatrie. 203:220-230
The neoadjuvant study COSS-86 was undertaken aiming at (1) improving the cure rate in osteosarcoma by early intensification of chemotherapy in high risk patients and (2) investigating the effect of intraarterial (i.a.) versus intravenous (i.v.) admin
Autor:
M. Salzer-Kuntschik, J. Dunst, R. Kürten, Rolf Sauer, J. M. V. Burgers, W. Winkelmann, R. Hawliczek, H. Jürgens, M. Müschenich
Publikováno v:
Cancer. 67:2818-2825
The Cooperative Ewing's Sarcoma Studies, CESS 81 and CESS 86, are multiinstitutional trials with more than 80 participating institutions from Germany, the Netherlands, Austria, and Switzerland. Treatment consists of four courses of multiagent chemoth
Autor:
S, Bielack, B, Kempf-Bielack, D, Schwenzer, T, Birkfellner, G, Delling, V, Ewerbeck, G U, Exner, N, Fuchs, U, Göbel, N, Graf, U, Heise, K, Helmke, A R, von Hochstetter, H, Jürgens, R, Maas, N, Münchow, M, Salzer-Kuntschik, J, Treuner, U, Veltmann, M, Werner, W, Winkelmann, A, Zoubek, R, Kotz
Publikováno v:
Klinische Padiatrie. 211(4)
Owing to twenty years of multicentric interdisciplinary cooperation, the COSS group has been able to collect data on a large group of osteosarcoma patients treated by neoadjuvant therapy. This paper reviews results achieved in patients with localized
Autor:
M, Salzer-Kuntschik
Publikováno v:
Verhandlungen der Deutschen Gesellschaft fur Pathologie. 82
Osteoclast-like giant cells (GC) may dominate the histologic pattern not only in conventional giant-cell tumor (GCT)--originating as a radiologically pure lytic, possibly trabeculated lesion especially within the epiphyses of long tubular bones (LB)
Autor:
N. Fuchs, Norbert Graf, Dieter Körholz, D Epler, M. Salzer-Kuntschik, Heribert Jürgens, Rainer Kotz, P. Weinel, G. Delling, P Bieling, Mathias Werner, K. Winkler, Stefan S. Bielack, U. Heise
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 9(8)
Summary Background: In an effort to intensify osteosarcoma therapy, systemic ifosfamide was added pre- and postoperatively to an already aggressive three-drug regimen. In a subgroup of patients, loco-regional treatment intensification was attempted b