Zobrazeno 1 - 10
of 120
pro vyhledávání: '"M S Meltzer"'
Publikováno v:
The Journal of Immunology. 156:2481-2487
IFN-alpha is an antiviral cytokine detected in plasma of HIV-1-infected patients during acute viremia and during late-stage disease. Monocytes produced IFN-alpha in response to HIV-1:1) IFN-alpha was produced predominantly by adherent cells; 2) deple
Publikováno v:
The Journal of Immunology. 153:1238-1245
Alveolar macrophages (AMs) were analyzed for ability to support replication of the intracellular bacterium Francisella tularensis live vaccine strain (LVS). AM supported in vitro growth (2 to 3 logs over 5 days) of LVS with a doubling time of 8 +/- 0
Autor:
M L Francis, M S Meltzer
Publikováno v:
The Journal of Immunology. 151:2208-2216
IFN-alpha is in plasma of HIV-1 infected patients during early and late-stage disease and may play a role in control of virus replication. The stimulus for IFN-alpha production, the cells that produce this cytokine, and the effectiveness of this IFN-
Publikováno v:
The Journal of Immunology. 148:2539-2546
Vitamin A and other retinoids have profound effects on macrophage differentiation and function. Such effects could alter interactions between HIV and tissue macrophages, a principal target cell and reservoir for virus during HIV disease. Indeed, reti
Publikováno v:
The Journal of Immunology. 146:3396-3404
Several reports implicate Langerhans cells of skin as susceptible targets, reservoirs, and vectors for transmission of HIV: 1) numbers of Langerhans cells in skin of HIV-infected patients were decreased about 50% of that in control skin; 2) as many a
Publikováno v:
The Journal of Immunology. 146:1316-1321
Inasmuch as the exact level of CD4 Ag expression on macrophages is controversial and because HIV may interact with macrophages in a manner different from that on T cells, we analyzed the binding of gp120 to freshly isolated and cultured monocytes. rg
Autor:
D C Kalter, M Nakamura, J A Turpin, L M Baca, D L Hoover, C Dieffenbach, P Ralph, H E Gendelman, M S Meltzer
Publikováno v:
The Journal of Immunology. 146:298-306
Monocytes cultured 7 to 10 days in recombinant human macrophage CSF (MCSF) were greater than 400-fold more susceptible to HIV infection than an equal number of cells cultured in medium alone. Levels of reverse transcriptase activity and p24 Ag in cul
Publikováno v:
The Journal of Immunology. 145:4290-4297
Macrophages exposed to IFN-gamma and infected with amastigotes of Leishmania major develop the capacity to eliminate the intracellular pathogen. This antimicrobial activity of activated macrophages correlates with the initiation of nitrogen oxidation
Autor:
H E Gendelman, L M Baca, J Turpin, D C Kalter, B Hansen, J M Orenstein, C W Dieffenbach, R M Friedman, M S Meltzer
Publikováno v:
The Journal of Immunology. 145:2669-2676
In a survey of 15 different virus isolates, no IFN-alpha or IFN-beta activity was detected in culture fluids of HIV-infected T cells or monocytes. Exogenous rIFN-alpha added to T lymphoblast or monocyte cultures induced restriction in replication of
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(7)
IFN-alpha is an antiviral cytokine detected in plasma of HIV-1-infected patients during acute viremia and during late-stage disease. Monocytes produced IFN-alpha in response to HIV-1:1) IFN-alpha was produced predominantly by adherent cells; 2) deple