Zobrazeno 1 - 10
of 32
pro vyhledávání: '"M S Lau"'
Autor:
Jordan Staunton, Pamela Ajuyah, Angela Harris, Chelsea Mayoh, Marie Wong, Megan Rumford, Patricia J. Sullivan, Paul G. Ekert, Noemi Fuentes-Bolanos, Mark J. Cowley, Loretta M. S. Lau, David S. Ziegler, Paulette Barahona, Neevika Manoharan
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Noonan Syndrome (NS) is associated with an increased risk of low-grade central nervous system tumours in children but only very rarely associated with high-grade gliomas. Here we describe the first reported case of a spinal high-grade astroc
Externí odkaz:
https://doaj.org/article/f3ea3867fb7b4b96ba99217da50f78f6
Autor:
S. J. Jessop, N. Fuentos‐Bolanos, C. Mayoh, M. E. M. Dolman, G. Tax, M. Wong‐Erasmus, P. Ajuyah, V. Tyrell, G. M. Marshall, D. S. Ziegler, L. M. S. Lau
Publikováno v:
Cancer Reports, Vol 7, Iss 4, Pp n/a-n/a (2024)
Abstract Background Despite advances in therapeutics for adverse‐risk acute myeloid leukaemia (AML), overall survival remains poor, especially in refractory disease. Comprehensive tumour profiling and pre‐clinical drug testing can identify effect
Externí odkaz:
https://doaj.org/article/a1e5a028813d4920bdd7d8ade437319d
Autor:
Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a
Externí odkaz:
https://doaj.org/article/fbd7979e6f4b4aebb70a711623639d1f
Autor:
Pamela Ajuyah, Chelsea Mayoh, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Hazel Chambers, Fatima Valdes-Mora, Akanksha Senapati, Andrew J. Gifford, Colleen D’Arcy, Jordan R. Hansford, Neevika Manoharan, Wayne Nicholls, Molly M. Williams, Paul J. Wood, Mark J. Cowley, Vanessa Tyrrell, Michelle Haber, Paul G. Ekert, David S. Ziegler, Dong-Anh Khuong-Quang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been described with similar features to DMG, including loss of H3K27 trimethylation, but la
Externí odkaz:
https://doaj.org/article/8e8fabf3268f4381b287194aa795890c
Autor:
Yuyan Chen, Mark Pinese, Claire Wakefield, Frank Alvaro, Katherine Tucker, Tracey A O’Brien, Vanessa J Tyrrell, Judy Kirk, Kate Hetherington, Eliza Courtney, Kristine Barlow-Stewart, Noemi Auxiliadora Fuentes Bolanos, Bhavna Padhye, Macabe Daley, Jacqueline Hunter, Meera Warby, Sarah Josephi-Taylor, Marie Wong-Erasmus, Paulette Barahona, Pamela Ajuyah, Ann-Kristin Altekoester, Loretta M S Lau, Dianne Sylvester, Luciano Dalla Pozza
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Introduction Identifying an underlying germline cancer predisposition (CP) in a child with cancer has potentially significant implications for both the child and biological relatives. Cohort studies indicate that 10%–15% of paediatric cancer patien
Externí odkaz:
https://doaj.org/article/da226946131d4fd0bb6f8385a8b6d90d
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
Autor:
Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-15 (2021)
Abstract Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a precision medicine platform of rapid high‐throughput drug screening (HTS) and patient‐
Externí odkaz:
https://doaj.org/article/f2db646d5831450d847f4d18a36cdea2
Autor:
Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta M. S. Lau, Paul G. Ekert, David S. Ziegler
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common radiological and histopathological features but the clinical course of this disease is variab
Externí odkaz:
https://doaj.org/article/2fffe9ecbf6a45a3a78cee93cf94d83d
Autor:
Sumanth Nagabushan, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Alexandra Sherstyuk, Glenn M. Marshall, Vanessa Tyrrell, Eva A. Wegner, Paul G. Ekert, Mark J. Cowley, Chelsea Mayoh, Toby N. Trahair, Philip Crowe, Antoinette Anazodo, David S. Ziegler
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)
Abstract The prognosis of recurrent malignant peripheral nerve sheath tumors (MPNST) is dismal, with surgical resection being the only definitive salvage therapy. Treatment with chemoradiation approaches has not significantly improved patient outcome
Externí odkaz:
https://doaj.org/article/1017be47b03249d190e20ce279c78746
Autor:
Wakefield, Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta M. S. Lau, Toby N. Trahair, Tracey A. O’Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E.
Publikováno v:
Journal of Personalized Medicine; Volume 13; Issue 7; Pages: 1033
Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e5c5bf19859e2be8494ce46fbbed9d3c
Autor:
W Y Tse, C T Y Yan, Linda Lam, C F Chan, P. F. Pang, Mimi Mc Wong, J Tsoh, S K L Lee, M S Lau
Publikováno v:
East Asian Archives of Psychiatry. 31:67-70
Objective To compare predictive validity of the Wilson Sims Fall Risk Assessment Tool (WSFRAT) with that of the Morse Fall Scale (MFS) in psychogeriatric inpatients. Methods Psychogeriatric patients from Shatin Hospital, Tai Po Hospital, Castle Peak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99f5fc7412976392ea81ed74c2ca6e0
https://doi.org/10.12809/eaap2113
https://doi.org/10.12809/eaap2113